Activity of temafloxacin and other fluoroquinolones against typical and atypical community-acquired respiratory tract pathogens.

Abstract

The microbiologic activities of temafloxacin, ciprofloxacin, and ofloxacin against community-acquired respiratory tract pathogens are reviewed. The 90% minimal inhibitory concentrations (MIC90s) of these fluoroquinolones for gram-negative pathogens were generally comparable, that is, less than 0.06 micrograms/mL. Overall, the agents were less active against gram-positive pathogens, although temafloxacin was two- to fourfold more active than the other agents against staphylococci and streptococci. For strains of Mycoplasma pneumoniae and Chlamydia pneumoniae, temafloxacin was generally inhibitory at concentrations of 0.5-2 micrograms/mL. This microbiologic activity, combined with its pharmacokinetic profile, should make temafloxacin a useful antimicrobial agent for treating community-acquired respiratory tract infections.

• Authors: D J Hardy
• Journal: The American journal of medicine (Am J Med) Vol. 91 Issue 6A Pg. 12S-14S (Dec 30 1991) ISSN: 0002-9343 [Print] United States
• PMID: 1662881 (Publication Type: Journal Article)

Chemical References

• Anti-Infective Agents
• Fluoroquinolones
• Quinolones
• temafloxacin
• Ciprofloxacin
• Ofloxacin

Topics

• Anti-Infective Agents (pharmacology)
• Bacteria (drug effects)
• Ciprofloxacin (pharmacology)
• Fluoroquinolones
• Humans
• Microbial Sensitivity Tests
• Ofloxacin (pharmacology)
• Quinolones (pharmacology)
• Respiratory Tract Infections (microbiology)