Joint effect among p53, CYP1A1, GSTM1 polymorphism combinations and smoking on prostate cancer risk: an exploratory genotype-environment interaction study.

Abstract

AIM:

To assess the role of several genetic factors in combination with an environmental factor as modulators of prostate cancer risk. We focus on allele variants of low-penetrance genes associated with cell control, the detoxification processes and smoking.

METHODS:

In a case-control study we compared people carrying p53cd72 Pro allele, CYP1A1 M1 allele and GSTM1 null genotypes with their prostate cancer risk.

RESULTS:

The joint risk for smokers carrying Pro* and M1*, Pro* and GSTM1null or GSTM1 null and CYP1A1 M1* variants was significantly higher (odds ratio [OR]: 13.13, 95% confidence interval [CI]: 2.41-71.36; OR: 3.97, 95% CI: 1.13-13.95 and OR: 6.87, 95% CI: 1.68-27.97, respectively) compared with that for the reference group, and for non-smokers was not significant. OR for combinations among p53cd72, GSTM1 and CYP1A1 M1 in smokers were positively and significantly associated with prostate cancer risk compared with non-smokers and compared with the putative lowest risk group (OR: 8.87, 95% CI: 1.25-62.71).

CONCLUSION:

Our results suggest that a combination of p53cd72, CYP1A1, GSTM1 alleles and smoking plays a significant role in modified prostate cancer risk on the study population, which means that smokers carrying susceptible genotypes might have a significantly higher risk than those carrying non-susceptible genotypes.

• Authors: Luis A Quiñones, Carlos E Irarrázabal, Claudio R Rojas, Cristian E Orellana, Cristian Acevedo, Christian Huidobro, Nelson E Varela, Dante D Cáceres
• Journal: Asian journal of andrology (Asian J Androl) Vol. 8 Issue 3 Pg. 349-55 (May 2006) ISSN: 1008-682X [Print] China
• PMID: 16625286 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cytochrome P-450 CYP1A1
• Glutathione Transferase
• glutathione S-transferase M1

Topics

• Aged
• Confidence Intervals
• Cytochrome P-450 CYP1A1 (genetics)
• Gene Amplification
• Genes, p53
• Genetic Variation
• Genotype
• Glutathione Transferase (genetics)
• Humans
• Male
• Middle Aged
• Polymerase Chain Reaction
• Polymorphism, Genetic
• Prostatic Neoplasms (epidemiology, genetics)
• Risk Factors
• Smoking