Abstract | PURPOSE OF INVESTIGATION: The aim of the study was to investigate the role of fascin in tumor progression and to investigate the role of fascin on endothelial cell migration and angiogenesis in ovarian neoplasms. METHODS: RESULTS: Total stromal fascin score in cases of borderline and malign epithelial ovarian tumors was significantly higher compared to normal ovaries and benign epithelial ovarian tumors (.000, p < 0.001). There was no statistically significant difference in terms of total epithelial fascin scores of samples between groups (.080, p > 0.05). Presence of vascular invasion (.000, p < 0.001), psammomatous calcifications (.001, p = 0.001), and lymphocytic infiltration (.000, p < 0.001) were significantly higher in malign neoplasms. There was no significant difference in terms of mean microvessel count and homogeneous or heterogeneous fascin expression of microvessels between the benign and malign groups (respectively p = .228 and p = .143). CONCLUSIONS: This study suggests that up-regulation of fascin in tumoral tissue may promote invasion of ovarian carcinoma by cell-matrix adhesion.
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Authors | S Kabukcuoglu, U Oner, S S Ozalp, K Bildirici, O T Yalcin, E Colak |
Journal | European journal of gynaecological oncology
(Eur J Gynaecol Oncol)
Vol. 27
Issue 2
Pg. 171-6
( 2006)
ISSN: 0392-2936 [Print] Singapore |
PMID | 16620064
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Actins
- Antibodies, Monoclonal
- Carrier Proteins
- Microfilament Proteins
- fascin
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Topics |
- Actins
(metabolism)
- Antibodies, Monoclonal
- Carrier Proteins
(metabolism)
- Cell-Matrix Junctions
(pathology)
- Cystadenoma, Mucinous
(metabolism, pathology, surgery)
- Disease Progression
- Female
- Humans
- Immunohistochemistry
- Microfilament Proteins
(metabolism)
- Neoplasms, Glandular and Epithelial
- Neovascularization, Pathologic
(pathology)
- Ovarian Neoplasms
(blood, metabolism, pathology)
- Up-Regulation
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