Cleft of the secondary palate without cleft lip diagnosed with three-dimensional ultrasound and magnetic resonance imaging in a fetus with Fryns' syndrome.

We present a case of Fryns' syndrome diagnosed prenatally using three-dimensional (3D) ultrasonography and magnetic resonance imaging (MRI). A cleft of the soft palate was diagnosed using 3D thick-slice ultrasonography. Other sonographic findings included a right diaphragmatic hernia, enlarged echogenic kidneys and severe polyhydramnios. The detection of the cleft palate was instrumental in suggesting the diagnosis of Fryns' syndrome in a fetus which also had a diaphragmatic hernia. These findings were also demonstrated with prenatal MRI. The technique of imaging the soft palate en face using a thick-slice technique is presented.
AuthorsB R Benacerraf, P M Sadow, C E Barnewolt, J A Estroff, C Benson
JournalUltrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology (Ultrasound Obstet Gynecol) Vol. 27 Issue 5 Pg. 566-70 (May 2006) ISSN: 0960-7692 [Print] England
PMID16619385 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright 2006 ISUOG
  • Abnormalities, Multiple (ultrasonography)
  • Cleft Palate (ultrasonography)
  • Craniofacial Abnormalities (ultrasonography)
  • Female
  • Fetal Death
  • Hernia, Diaphragmatic (ultrasonography)
  • Humans
  • Image Processing, Computer-Assisted
  • Imaging, Three-Dimensional
  • Kidney (abnormalities)
  • Magnetic Resonance Imaging
  • Palate, Soft (ultrasonography)
  • Pregnancy
  • Syndrome
  • Ultrasonography, Prenatal

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: