Cleft of the secondary palate without cleft lip diagnosed with three-dimensional ultrasound and magnetic resonance imaging in a fetus with Fryns' syndrome.

Abstract

We present a case of Fryns' syndrome diagnosed prenatally using three-dimensional (3D) ultrasonography and magnetic resonance imaging (MRI). A cleft of the soft palate was diagnosed using 3D thick-slice ultrasonography. Other sonographic findings included a right diaphragmatic hernia, enlarged echogenic kidneys and severe polyhydramnios. The detection of the cleft palate was instrumental in suggesting the diagnosis of Fryns' syndrome in a fetus which also had a diaphragmatic hernia. These findings were also demonstrated with prenatal MRI. The technique of imaging the soft palate en face using a thick-slice technique is presented.

• Authors: B R Benacerraf, P M Sadow, C E Barnewolt, J A Estroff, C Benson
• Journal: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology (Ultrasound Obstet Gynecol) Vol. 27 Issue 5 Pg. 566-70 (May 2006) ISSN: 0960-7692 [Print] England
• PMID: 16619385 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright 2006 ISUOG

Topics

• Abnormalities, Multiple (diagnostic imaging)
• Cleft Palate (diagnostic imaging)
• Craniofacial Abnormalities (diagnostic imaging)
• Female
• Fetal Death
• Hernia, Diaphragmatic (diagnostic imaging)
• Humans
• Image Processing, Computer-Assisted
• Imaging, Three-Dimensional
• Kidney (abnormalities)
• Magnetic Resonance Imaging
• Palate, Soft (diagnostic imaging)
• Pregnancy
• Syndrome
• Ultrasonography, Prenatal