The efficacy of the thyroid peroxidase marker for distinguishing follicular thyroid carcinoma from follicular adenoma.

Abstract

AIM:

Expression of thyroid peroxidase (TPO) in the thyroid gland tissue is well known as a sensitive marker of the thyroid malignancy. We have evaluated immunohistochemical assay of TPO for distinguishing follicular thyroid carcinoma from follicular adenoma.

MATERIALS AND METHODS:

Sections of formalin-fixed tissues obtained from 92 patients with thyroid tumors (52 follicular carcinomas and 40 follicular adenomas including the Hurthle cell type) were analyzed using a monoclonal antibody (TPO mAb 47) and the avidin-biotin peroxidase complex immunohistochemical technique. Lesions with staining of more than 80% of the follicular cells/specimen were considered benign, while less than 80% were considered malignant.

RESULTS:

TPO immunostaining correlated with the histopathological diagnosis in 24/40 cases of follicular adenomas and 41/52 cases of follicular carcinomas, giving a specificity of 60% and a sensitivity of 79%.

CONCLUSION:

These results suggest that immunohistochemical assay of TPO expression has limited value for the differential diagnosis of follicular thyroid carcinoma from thyroid follicular adenoma.

• Authors: S Savin, D Cvejic, T Isic, I Paunovic, S Tatic, M Havelka
• Journal: Experimental oncology (Exp Oncol) Vol. 28 Issue 1 Pg. 70-4 (Mar 2006) ISSN: 1812-9269 [Print] Ukraine
• PMID: 16614712 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Iodide Peroxidase

Topics

• Adenocarcinoma, Follicular (diagnosis, enzymology, pathology)
• Adenoma (diagnosis, enzymology, pathology)
• Biomarkers, Tumor (analysis)
• Diagnosis, Differential
• Humans
• Immunohistochemistry
• Iodide Peroxidase (metabolism)
• Thyroid Neoplasms (diagnosis, enzymology, pathology)