Regression of skeletal manifestations of hyperparathyroidism with oral vitamin D.

Abstract

CONTEXT:

Parathyroidectomy is the only effective therapy for osteitis fibrosa cystica in hyperparathyroidism.

OBJECTIVE:

The objective of this study was to describe the changes of skeletal and nonskeletal manifestations in a patient with hyperparathyroidism and renal failure after oral vitamin D therapy.

DESIGN:

This was a descriptive case report.

SETTING:

The patient was followed up in a referral center.

PATIENT:

A 55-yr-old male patient with moderate renal failure was referred for expansile lytic lesions affecting several ribs and the spinous process of T12. His creatinine was 1.8 mg/dl; calcium, 8.9 mg/dl; PTH, 666 pg/ml; and 1,25 dihydroxy-vitamin D, 27 pg/ml. Bone mineral density (BMD) Z-scores by dual-energy x-ray absorptiometry were -4.1 at the spine, -1.7 at the hip, and -4.3 at the forearm.

MAIN OUTCOME MEASURES:

The main outcome measures were the skeletal manifestations of hyperparathyroidism.

RESULTS:

At 10 months of therapy, calcium level was 10 mg/d, PTH level declined to 71 pg/ml, and BMD increased by 12% at the spine and 18% at the hip. Computerized tomography (CT) cuts revealed marked regression in the lytic lesions. At 2 yr, BMD increased by an additional 6% at the spine, and there were no further changes in the lytic lesions by CT. The vitamin D receptor genotype using the restriction enzymes Bsm1, Taq1, and Apa1 was Bb, tt, and AA.

CONCLUSIONS:

We showed regression of severe skeletal abnormalities of hyperparathyroidism documented by serial CT images in response to oral vitamin D therapy. It is possible that the vitamin D receptor genotype of the patient modulated this response.

• Authors: Asma Arabi, Nabil Khoury, Laila Zahed, Adel Birbari, Ghada El-Hajj Fuleihan
• Journal: The Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 91 Issue 7 Pg. 2480-3 (Jul 2006) ISSN: 0021-972X [Print] United States
• PMID: 16608887 (Publication Type: Case Reports, Journal Article)

Chemical References

• Hydroxycholecalciferols
• Receptors, Calcitriol
• Vitamin D
• Cholecalciferol
• Calcium
• alfacalcidol

Topics

• Bone Density
• Bone Diseases (diagnosis, drug therapy, etiology)
• Calcium (blood, urine)
• Cholecalciferol (administration & dosage)
• Genotype
• Humans
• Hydroxycholecalciferols (administration & dosage)
• Hyperparathyroidism, Secondary (complications, drug therapy)
• Kidney Failure, Chronic (complications)
• Male
• Middle Aged
• Osteitis Fibrosa Cystica (diagnosis, drug therapy, etiology)
• Osteoporosis (diagnosis, drug therapy, etiology)
• Receptors, Calcitriol (genetics)
• Thalassemia (complications)
• Tomography, X-Ray Computed
• Vitamin D (therapeutic use)