[Heparin-associated thrombocytopenia, thrombosis and embolism. Side effects of thromboembolism prevention with low molecular weight heparin enoxaparin?].

Abstract

Heparin-associated thrombocytopenia (HAT) is a rarely described adverse reaction of systemic administration of heparin that may be complicated by thrombosis, embolism and bleeding. Unfractionated heparin as well as low molecular weight heparin may provoke HAT. A case of HAT complicated by thrombosis and pulmonary embolism is described that came about during preventive postoperative anticoagulation with the low molecular weight heparin enoxaparin. Pathogenesis, diagnosis, prophylaxis and therapy of HAT are discussed.

• Authors: V D Mohr, J Lenz
• Journal: Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen (Chirurg) Vol. 62 Issue 9 Pg. 686-90 (Sep 1991) ISSN: 0009-4722 [Print] Germany
• Vernacular Title: Heparin-assoziierte Thrombocytopenie, Thrombose und Embolie. Unerwünschte Wirkung der Thromboembolieprophylaxe mit dem niedermolekularen Heparin Enoxaparin?
• PMID: 1660803 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Heparin, Low-Molecular-Weight
• Phenprocoumon
• Aspirin

Topics

• Aged
• Aspirin (administration & dosage)
• Blood Coagulation Tests
• Carcinoma, Renal Cell (blood, surgery)
• Heparin, Low-Molecular-Weight (administration & dosage, adverse effects)
• Humans
• Kidney Neoplasms (blood, surgery)
• Male
• Nephrectomy
• Phenprocoumon (administration & dosage)
• Platelet Aggregation (drug effects)
• Platelet Count (drug effects)
• Postoperative Complications (blood, prevention & control)
• Pulmonary Embolism (blood, chemically induced, prevention & control)
• Thrombocytopenia (blood, chemically induced)
• Thrombophlebitis (blood, chemically induced, prevention & control)