Haplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance.

Abstract

We studied single nucleotide polymorphisms (SNPs) and haplotypes in the urotensin-II (UTS2) and urotensin-II receptor gene (UTS2R) in Hong Kong Chinese (224 hypertensive and 306 normotensive unrelated subjects) and their relation to hypertension and the metabolic syndrome. For UTS2, the GGT haplotype (-605G, 143G and 3836T) was associated with higher plasma level of U-II and insulin, and higher homeostasis model assessment of insulin resistance index and beta-cell function. For UTS2R, the AC haplotype (-11640A and -8515C) was associated with higher 2 h plasma glucose after a 75 g oral glucose load. Therefore, U-II and its receptor may play a role in insulin resistance.

• Authors: Kwok Leung Ong, Louisa Y F Wong, Yu Bun Man, Raymond Y H Leung, You-Qiang Song, Karen S L Lam, Bernard M Y Cheung
• Journal: Peptides (Peptides) Vol. 27 Issue 7 Pg. 1659-67 (Jul 2006) ISSN: 0196-9781 [Print] United States
• PMID: 16597476 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Receptors, G-Protein-Coupled
• UTS2R protein, human
• Urotensins
• urotensin II

Topics

• Alleles
• Base Sequence
• Female
• Gene Frequency
• Genotype
• Glucose Tolerance Test
• Haplotypes
• Humans
• Hypertension (blood, genetics)
• Insulin Resistance
• Linkage Disequilibrium
• Male
• Models, Genetic
• Molecular Sequence Data
• Polymorphism, Single Nucleotide
• Receptors, G-Protein-Coupled (genetics)
• Urotensins (genetics, metabolism)