HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Expression of thrombospondin 1 (TSP 1) in patients with uterine smooth muscle tumors: an immunohistochemical study.

AbstractOBJECTIVE:
Angiogenesis is an essential component for tumor development regulated by both proangiogenic and antiangiogenic factors. Thrombospondin 1 (TSP 1) suppresses angiogenesis by inhibiting endothelial cell proliferation and inducing endothelial cell apoptosis. The aim of this study was to compare the expression of TSP 1 in cases with leiomyoma, uterine smooth muscle tumor of uncertain malignant potential (STUMP) and leiomyosarcoma (LMS). Furthermore, we evaluated the prognostic relevance of TSP 1 in uterine LMS.
METHODS:
TSP 1 expression was investigated by immunohistochemistry from paraffin-embedded tissue in 26 patients with leiomyoma, in 24 patients with STUMP and in 21 patients with LMS. Standard immunohistochemical techniques were used to study the expression of TSP 1 in 5-mum-thick tumor sections. TSP 1 expression was correlated with survival using the Kaplan-Meier method and log-rank test for univariate analysis.
RESULTS:
TSP 1 was expressed in 77% of leiomyomas, in 13% of STUMP and in 24% of LMS. A statistically significant difference regarding the frequency of TSP 1 expression was observed between leiomyoma and LMS (P < 0.05) as well as between leiomyoma and STUMP (P < 0.05), but not between LMS and STUMP (P > 0.05). Furthermore, a statistically significant correlation between vascular space involvement and TSP 1 expression was observed in patients with uterine LMS, with patients without vascular space involvement having more frequently TSP 1 positive tumors (P = 0.04). No statistically significant correlation between TSP 1 and clinical stage, age and recurrence disease could be detected (P > 0.05).
CONCLUSIONS:
We found that TSP 1 was more frequently expressed in leiomyoma compared to STUMP and LMS. Additionally, the statistically significant negative correlation between vascular space involvement and TSP 1 expression in patients with uterine LMS shows that TSP 1 might work as a predictive factor in patients with LMS. Further clinical studies are necessary to prove our results and to clarify the role of TSP 1 in uterine smooth muscle tumors.
AuthorsBarbara Bodner-Adler, Andreas Nather, Klaus Bodner, Klaus Czerwenka, Oliver Kimberger, Sepp Leodolter, Klaus Mayerhofer
JournalGynecologic oncology (Gynecol Oncol) Vol. 103 Issue 1 Pg. 186-9 (Oct 2006) ISSN: 0090-8258 [Print] United States
PMID16595146 (Publication Type: Journal Article)
Chemical References
  • Thrombospondin 1
Topics
  • Female
  • Humans
  • Immunohistochemistry
  • Leiomyoma (blood supply, metabolism, pathology)
  • Leiomyosarcoma (blood supply, metabolism, pathology)
  • Middle Aged
  • Neoplasm Staging
  • Neovascularization, Pathologic (metabolism)
  • Retrospective Studies
  • Smooth Muscle Tumor (blood supply, metabolism, pathology)
  • Thrombospondin 1 (biosynthesis)
  • Uterine Neoplasms (blood supply, metabolism, pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: