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Clozapine in schizophrenia patients with recurrent catatonia: report of two cases.

Abstract
Prolonged catatonia can be a source of extremely serious morbidity and mortality. Lorazepam is effective in rapidly relieving most cases of catatonia. Reports have also shown that second-generation antipsychotic drugs are also efficacious in relieving catatonia. This report describes two schizophrenia patients who demonstrated recurrent catatonic features mutism and stupor. Both patients were treated with lorazepam, diazepam or electroconvulsive therapy (ECT). Patient 1 responded well and rapidly to lorazepam each time catatonia happened; but catatonia recurred once a year under treatment with many antipsychotic drugs. Patient 2 had catatonia features associated with discontinuing or decreasing clozapine. With each recurrent episode, the duration of catatonia increased, requiring an increased dosage of benzodiazepine. The patient's response to lorazepam and ECT gradually decreased, until the patient had almost no response to lorazepam, diazepam or ECT. Both patients had no recurrence during a period of 2-year follow up with continuous clozapine therapy.
AuthorsYi-Yung Hung, Ping-Suen Yang, Tiao-Lai Huang
JournalPsychiatry and clinical neurosciences (Psychiatry Clin Neurosci) Vol. 60 Issue 2 Pg. 256-8 (Apr 2006) ISSN: 1323-1316 [Print] Australia
PMID16594953 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antipsychotic Agents
  • Clozapine
Topics
  • Adult
  • Antipsychotic Agents (administration & dosage, therapeutic use)
  • Catatonia (etiology)
  • Clozapine (administration & dosage, therapeutic use)
  • Female
  • Humans
  • Recurrence
  • Schizophrenia (complications, drug therapy)
  • Treatment Outcome

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