Cardiac troponins as indicators of acute myocardial damage in dogs.

Abstract

Cardiac troponin I (cTnI) and T (cTnT) have a high sequence homology across phyla and are sensitive and specific markers of myocardial damage. The purpose of this study was to evaluate the Cardiac Reader, a human point-of-care system for the determination of cTnT and myoglobin, and the Abbott Axsym System for the determination of cTnI and creatine kinase isoenzyme MB (CK-MB) in healthy dogs and in dogs at risk for acute myocardial damage because of gastric dilatation-volvulus (GDV) and blunt chest trauma (BCT). In healthy dogs (n = 56), cTnI was below detection limits (<0.1 microg/L) in 35 of 56 dogs (reference range 0-0.7 microg/L), and cTnT was not measurable (<0.05 ng/mL) in all but 1 dog. At presentation, cTnI, CK-MB, myoglobin, and lactic acid were all significantly higher in dogs with GDV (n = 28) and BCT (n = 8) than in control dogs (P < .001), but cTnT was significantly higher only in dogs with BCT (P = .033). Increased cTnI or cTnT values were found in 26 of 28 (highest values 1.1-369 microg/L) and 16 of 28 dogs (0.1-1.7 ng/mL) with GDV, and in 6 of 8 (2.3-82.4 microg/L) and 3 of 8 dogs (0.1-0.29 ng/mL) with BCT, respectively. In dogs suffering from GDV, cTnI and cTnT increased further within the first 48 hours (P < .001). Increased cardiac troponins suggestive of myocardial damage occurred in 93% of dogs with GDV and 75% with BCT. cTnI appeared more sensitive, but cTnT may be a negative prognostic indicator in GDV. Both systems tested seemed applicable for the measurement of canine cardiac troponins, with the Cardiac Reader particularly suitable for use in emergency settings.

• Authors: Iwan A Burgener, Alan Kovacevic, G Neal Mauldin, Christophe W Lombard
• Journal: Journal of veterinary internal medicine (J Vet Intern Med) 2006 Mar-Apr Vol. 20 Issue 2 Pg. 277-83 ISSN: 0891-6640 [Print] United States
• PMID: 16594583 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Myoglobin
• Reagent Kits, Diagnostic
• Troponin C
• Troponin I

Topics

• Animals
• Biomarkers
• Dog Diseases (blood, diagnosis)
• Dogs
• Female
• Gastric Dilatation (veterinary)
• Heart Diseases (blood, diagnosis, veterinary)
• Male
• Myoglobin (blood)
• Point-of-Care Systems
• Reagent Kits, Diagnostic (veterinary)
• Risk Factors
• Stomach Volvulus (veterinary)
• Troponin C (blood)
• Troponin I (blood)
• Wounds, Nonpenetrating (veterinary)