[Vagina cancer in a young woman exposed to diethylstilbestrol: case report and literature review].

Abstract

We analyzed a 20 year-old patient case exposed in utero to diethylstilbestrol, as probably predisposed factor in vaginal cancer. The histopathological report of the incisional biopsy was clear cell vaginal adenocarcinoma, stage III, widespread to the pelvic wall, with metastasis to regional lymph nodes, and lack of distant metastasis. We decided surgical management: protocolized laparotomy, peritoneal washing, retroperitoneal node biopsies and a radical hysterectomy, Piver III, with two thirds parts of vagina. By poor prognosis we decided to offer an adjuvant management, with systemic chemotherapy.

• Authors: Arturo Novoa Vargas, Conrado Grados García, Roberto Bustillos de Cima, Berenice Malagón Millán
• Journal: Ginecologia y obstetricia de Mexico (Ginecol Obstet Mex) Vol. 73 Issue 12 Pg. 666-73 (Dec 2005) ISSN: 0300-9041 [Print] Mexico
• Vernacular Title: Cáncer de vagina en una mujer joven expuesta a dietilestilbestrol: caso clínico y revisión de la bibliografía.
• PMID: 16583845 (Publication Type: Case Reports, Comparative Study, Journal Article)

Chemical References

• Diethylstilbestrol

Topics

• Adenocarcinoma, Clear Cell (chemically induced, diagnostic imaging, drug therapy, pathology, surgery)
• Adult
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Biopsy
• Chemotherapy, Adjuvant
• Diethylstilbestrol (adverse effects)
• Female
• Follow-Up Studies
• Humans
• Hysterectomy
• Lymphatic Metastasis
• Pregnancy
• Prenatal Exposure Delayed Effects
• Prognosis
• Radiography, Abdominal
• Time Factors
• Tomography, X-Ray Computed
• Vagina (pathology)
• Vaginal Neoplasms (chemically induced, diagnostic imaging, drug therapy, pathology, surgery)