Abstract | OBJECTIVE: METHODS: RESULTS: The left ventricular ejection fraction improved from 35.5% +/- 2.3% (mean +/- SEM) before surgery to 55.1% +/- 8.2% at 12 months (P < .01) in the myoblast group and from 33.6% +/- 9.3% to 38.6% +/- 11% in the control group. Regional contractility also improved in the myoblast group, particularly in cardiac segments treated with skeletal myoblasts (wall motion score index: 3.02 +/- 0.17 at baseline vs 1.36 +/- 0.14 at 12 months; P < .0001). Quantitative fluorine 18-fluorodeoxyglucose and nitrogen 13-ammonia positron emission tomography showed an increase in viability and perfusion 12 months after surgery both globally and in segments treated with myoblasts (P = .012 and P = .004). Skeletal myoblast implantation was not associated with adverse events or an increased incidence of cardiac arrhythmias. CONCLUSIONS: In patients with previous myocardial infarction, treatment with skeletal myoblasts in conjunction with coronary artery bypass is safe and feasible and is associated with an increased global and regional left ventricular function, improvement in viability, and perfusion of cardiac tissue and no significant incidence of arrhythmias.
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Authors | Juan J Gavira, Jesús Herreros, Ana Perez, María José Garcia-Velloso, Joaquín Barba, Francisco Martin-Herrero, Consuelo Cañizo, Ana Martin-Arnau, Josep M Martí-Climent, Milagros Hernández, Natalia López-Holgado, José María González-Santos, Cándido Martín-Luengo, Eduardo Alegria, Felipe Prósper |
Journal | The Journal of thoracic and cardiovascular surgery
(J Thorac Cardiovasc Surg)
Vol. 131
Issue 4
Pg. 799-804
(Apr 2006)
ISSN: 1097-685X [Electronic] United States |
PMID | 16580437
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Radiopharmaceuticals
- Fluorodeoxyglucose F18
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Cells, Cultured
- Chronic Disease
- Coronary Artery Bypass
- Echocardiography, Stress
- Feasibility Studies
- Female
- Fluorodeoxyglucose F18
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Myoblasts, Skeletal
(transplantation)
- Myocardial Contraction
- Myocardial Infarction
(diagnostic imaging, surgery)
- Myocardial Ischemia
(surgery)
- Positron-Emission Tomography
- Radiopharmaceuticals
- Stroke Volume
- Transplantation, Autologous
- Ventricular Function, Left
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