Abstract | BACKGROUND: METHODS: Children (age, 0.9 to 18 years) with CKD undergoing hemodialysis or peritoneal dialysis or with a glomerular filtration rate of 20 or greater and less than 60 mL/min/1.73 m2 (> or = 0.33 and < 1.00 mL/s/1.73 m2) were randomly assigned to the following treatment scheme: 2 weeks of washout followed by 8 weeks of treatment with either sevelamer or calcium acetate in a crossover fashion. Phosphorus, calcium, and intact parathyroid hormone in serum were measured every 2 weeks, and phosphate binder dosages were adjusted, if needed. Serum lipid and vitamin concentrations were measured at the beginning and end of each treatment period. The primary end point was the decrease in serum phosphorus levels after 8 weeks of treatment. RESULTS: CONCLUSION:
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Authors | Anne-Kathrin Pieper, Dieter Haffner, Bernd Hoppe, Katalin Dittrich, Gisela Offner, Klaus-Eugen Bonzel, Ulrike John, Stefan Fründ, Günter Klaus, Amrey Stübinger, Gesche Düker, Uwe Querfeld |
Journal | American journal of kidney diseases : the official journal of the National Kidney Foundation
(Am J Kidney Dis)
Vol. 47
Issue 4
Pg. 625-35
(Apr 2006)
ISSN: 1523-6838 [Electronic] United States |
PMID | 16564940
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Acetates
- Calcium Compounds
- Polyamines
- Sevelamer
- calcium acetate
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Topics |
- Acetates
(therapeutic use)
- Adolescent
- Calcium Compounds
- Child
- Child, Preschool
- Chronic Disease
- Cross-Over Studies
- Female
- Humans
- Infant
- Kidney Diseases
(drug therapy)
- Male
- Polyamines
(therapeutic use)
- Sevelamer
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