Antithrombotic effects of heparin and related agents.

Abstract

Native heparin was very effective in models of arterial and venous thrombosis as well as in a model demonstrating the effect on endothelial stability in rats. The effect on venous thrombosis was particularly prominent. The activities of LMW-heparin were about the same in all three models, the absolute effective dose against arterial thrombosis being much lower than with native heparin. A heparan sulfate-related preparation (suleparoide) was much less effective in both thrombosis models, especially in the venous one, while the activity was most specifically directed to the maintenance of endothelial stability.

• Authors: J Hladovec, F Kornalík
• Journal: Cor et vasa (Cor Vasa) Vol. 33 Issue 1 Pg. 68-74 ( 1991) ISSN: 0010-8650 [Print] Czech Republic
• PMID: 1655354 (Publication Type: Journal Article)

Chemical References

• Heparin, Low-Molecular-Weight
• Heparin
• Heparitin Sulfate

Topics

• Animals
• Dose-Response Relationship, Drug
• Endothelium, Vascular (drug effects)
• Female
• Heparin (pharmacology, therapeutic use)
• Heparin, Low-Molecular-Weight (pharmacology, therapeutic use)
• Heparitin Sulfate (pharmacology, therapeutic use)
• Rats
• Rats, Inbred Strains
• Thrombophlebitis (drug therapy)
• Thrombosis (drug therapy)