Abstract |
Licochalcone A (LicA), a major phenolic constituent of the licorice species Glycyrrhiza inflata, has recently been reported to have anti-inflammatory as well as anti-microbial effects. These anti-inflammatory properties might be exploited for topical applications of LicA. We conducted prospective randomized vehicle-controlled clinical trials to assess the anti-irritative efficacy of cosmetic formulations containing LicA in a post-shaving skin irritation model and on UV-induced erythema formation. The clinical trials were accompanied by a series of in vitro experiments to characterize anti-inflammatory properties of LicA on several dermatologically relevant cell types. Topical LicA causes a highly significant reduction in erythema relative to the vehicle control in both the shave- and UV-induced erythema tests, demonstrating the anti-irritative properties of LicA. Furthermore, LicA is a potent inhibitor of pro-inflammatory in vitro responses, including N-formyl-MET-LEU-PHE (fMLP)- or zymosan-induced oxidative burst of granulocytes, UVB-induced PGE(2) release by keratinocytes, lipopolysaccharide (LPS)-induced PGE(2) release by adult dermal fibroblasts, fMLP-induced LTB(4) release by granulocytes, and LPS-induced IL-6/TNF-alpha secretion by monocyte-derived dendritic cells. The reported data suggest therapeutic skin care benefits from LicA when applied to sensitive or irritated skin.
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Authors | Ludger Kolbe, Jeannine Immeyer, Jan Batzer, Ursula Wensorra, Karen tom Dieck, Claudia Mundt, Rainer Wolber, Franz Stäb, Uwe Schönrock, Roger I Ceilley, Horst Wenck |
Journal | Archives of dermatological research
(Arch Dermatol Res)
Vol. 298
Issue 1
Pg. 23-30
(Jun 2006)
ISSN: 0340-3696 [Print] Germany |
PMID | 16552540
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Inflammatory Agents
- Chalcones
- Interleukin-6
- Plant Extracts
- Tumor Necrosis Factor-alpha
- Leukotriene B4
- Zymosan
- licochalcone A
- Dinoprostone
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Topics |
- Administration, Topical
- Adult
- Anti-Inflammatory Agents
(administration & dosage, therapeutic use)
- Cells, Cultured
- Chalcones
(administration & dosage, therapeutic use)
- Dinoprostone
(metabolism)
- Erythema
(drug therapy, etiology, pathology)
- Granulocytes
(drug effects, metabolism, pathology)
- Humans
- Interleukin-6
(metabolism)
- Keratinocytes
(drug effects, metabolism, pathology)
- Leukotriene B4
(metabolism)
- Middle Aged
- Plant Extracts
(therapeutic use)
- Prospective Studies
- Respiratory Burst
(drug effects)
- Tumor Necrosis Factor-alpha
(metabolism)
- Ultraviolet Rays
(adverse effects)
- Zymosan
(pharmacology)
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