Abstract | PURPOSE: METHODS: This was a prospective, randomized, single masked, and parallel design study with 15 patients in each treatment group. After washout of any previous medications, each patient underwent a baseline 24-h IOP curve testing at 0600, 0900, 1200, 1500, 1800, 2100, and at 2400 (midnight) hours. Patients were then randomized to receive latanoprost, travoprost, or bimatoprost once a day for 3 months. The 24-h curve testing was repeated at first week, and first and third months. RESULTS: Maximal and minimal IOP was recorded at 0600 and 1800-2100 hours. There was no significant difference among treatment groups at any time-point except for the first week. At the first week, the travoprost group had significantly lower IOP levels than the latanoprost and bimatoprost groups. All medicines significantly lowered 24-h IOP from baseline (P=0.001 for each). Although there was no significant difference in IOP reduction among groups at first week and first month, bimatoprost reduced the 24-h IOP (7.9+/-1.4) more than travoprost (6.6+/-0.5) at the end of the third month (P=0.003). The mean 24-h range of IOP was lowest with travoprost in all visits, and between-group differences was significant for travoprost vslatanoprost (P=0.007) and travoprost vsbimatoprost (P=0.001) at the third month. CONCLUSION:
|
Authors | I F Hepsen, E Ozkaya |
Journal | Eye (London, England)
(Eye (Lond))
Vol. 21
Issue 4
Pg. 453-8
(Apr 2007)
ISSN: 0950-222X [Print] England |
PMID | 16543930
(Publication Type: Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Amides
- Antihypertensive Agents
- Lipids
- Prostaglandins F, Synthetic
- Cloprostenol
- Latanoprost
- Bimatoprost
- Travoprost
|
Topics |
- Amides
(therapeutic use)
- Antihypertensive Agents
(therapeutic use)
- Bimatoprost
- Cloprostenol
(analogs & derivatives, therapeutic use)
- Exfoliation Syndrome
(drug therapy)
- Female
- Humans
- Intraocular Pressure
(drug effects)
- Latanoprost
- Lipids
(therapeutic use)
- Male
- Middle Aged
- Ocular Hypertension
(drug therapy)
- Prospective Studies
- Prostaglandins F, Synthetic
(therapeutic use)
- Single-Blind Method
- Travoprost
- Treatment Outcome
|