Abstract | OBJECTIVES: The G1 regulators of the cell cycle, cyclin D(1) and D(3), have been implicated in the regulation of Schwann cell proliferation and differentiation. The purpose of this study is to evaluate cyclin D(1) and D(3) protein expression and the corresponding clinical characteristics of vestibular schwannomas. STUDY DESIGN AND METHODS: Tissue sections of 15 sporadic vestibular schwannomas were prepared. Immunohistochemical analysis of the vestibular schwannomas was performed with anticyclin D(1) and anticyclin D(3) antibodies. The immunoreactivity was evaluated in comparison with adjacent vestibular nerves. Tissue sections of breast carcinoma and prostate carcinoma were used as positive controls for cyclin D(1) and D(3) staining, respectively. Patient demographics, tumor characteristics, and cyclin D expression were reviewed, and statistical analysis was performed. RESULTS: CONCLUSION: The Cyclin D(1) protein does not appear to play a prominent role in promoting cell cycle progression in vestibular schwannomas. In contrast, cyclin D(3) expression was seen in nearly half of the tumors examined, suggesting that it may have a growth-promoting role in some schwannomas. Further studies are needed to define its cellular mechanism.
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Authors | Brian A Neff, Elly Oberstien, Mark Lorenz, Abhik R Chaudhury, D Bradley Welling, Long-Sheng Chang |
Journal | The Laryngoscope
(Laryngoscope)
Vol. 116
Issue 3
Pg. 423-6
(Mar 2006)
ISSN: 0023-852X [Print] United States |
PMID | 16540902
(Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Antibodies, Neoplasm
- Biomarkers, Tumor
- CCND3 protein, human
- Cyclin D3
- Cyclins
- Cyclin D1
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Topics |
- Antibodies, Neoplasm
(immunology)
- Biomarkers, Tumor
(metabolism)
- Breast Neoplasms
(immunology, metabolism, pathology)
- Carcinoma
(immunology, metabolism, pathology)
- Cyclin D1
(biosynthesis, immunology)
- Cyclin D3
- Cyclins
(biosynthesis, immunology)
- Diagnosis, Differential
- Female
- Humans
- Immunohistochemistry
- Male
- Neuroma, Acoustic
(immunology, metabolism, pathology)
- Prostatic Neoplasms
(immunology, metabolism, pathology)
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