[Expression and diagnostic significance of OCT4, CD117 and CD30 in germ cell tumors].
Abstract | OBJECTIVE: To study the immunohistochemical expression of OCT4, CD117 and CD30 in germ cell tumors and to assess their diagnostic value. METHODS: Immunohistochemical study for OCT4 was performed on formalin-fixed, paraffin-embedded tissues of 63 cases of germ cell tumors, including seminoma (21), dysgerminoma (7), germinoma (8), embryonal carcinoma (8), yolk sac tumor (6), mature teratoma (10) and immature teratoma (3), as well as 25 cases of non- germ cell tumors, including granulosa cell tumor (8), clear cell adenocarcinoma (4), Leydig's cell tumor (5), diffuse large B-cell lymphoma (4) and malignant melanoma (4). Besides, the expression of CD117 and CD30 in all germ cell tumors was studied. RESULTS: CONCLUSIONS:
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Authors | Liang-Hong Teng, De-Hong Lu, Qing-Zhong Xu, Yong-Juan Fu, Hong Yang, Zhi-Li He |
Journal | Zhonghua bing li xue za zhi = Chinese journal of pathology
(Zhonghua Bing Li Xue Za Zhi)
Vol. 34
Issue 11
Pg. 711-5
(Nov 2005)
ISSN: 0529-5807 [Print] China |
PMID | 16536313
(Publication Type: Journal Article)
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Chemical References |
- Ki-1 Antigen
- Octamer Transcription Factor-3
- Pou5f1 protein, mouse
- Proto-Oncogene Proteins c-kit
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Topics |
- Carcinoma, Embryonal
(metabolism, pathology)
- Diagnosis, Differential
- Dysgerminoma
(metabolism, pathology)
- Endodermal Sinus Tumor
(metabolism, pathology)
- Female
- Germinoma
(metabolism, pathology)
- Humans
- Ki-1 Antigen
(metabolism)
- Male
- Neoplasms, Germ Cell and Embryonal
(metabolism, pathology)
- Octamer Transcription Factor-3
(metabolism)
- Ovarian Neoplasms
(metabolism, pathology)
- Proto-Oncogene Proteins c-kit
(metabolism)
- Seminoma
(metabolism, pathology)
- Teratoma
(metabolism, pathology)
- Testicular Neoplasms
(metabolism, pathology)
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