Creatine monohydrate as a therapeutic aid in muscular dystrophy.

Abstract

In recent years, dietary supplementation with creatine has been shown to enhance neuromuscular function in several diseases. Recent studies have suggested that creatine can be beneficial in patients with muscular dystrophy and other mitochondrial cytopathies, and may attenuate sarcopenia and facilitate rehabilitation of disuse atrophy. Though the mechanisms are still unknown, creatine has been shown to decrease cytoplasmic Ca2+ levels and increase intramuscular and cerebral phosphocreatine stores, providing potential musculoskeletal and neuroprotective effects.

• Authors: Jared P Pearlman, Roger A Fielding
• Journal: Nutrition reviews (Nutr Rev) Vol. 64 Issue 2 Pt 1 Pg. 80-8 (Feb 2006) ISSN: 0029-6643 [Print] United States
• PMID: 16536185 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Review)

Chemical References

• Creatine
• Calcium

Topics

• Calcium (metabolism)
• Creatine (metabolism, therapeutic use)
• Dietary Supplements
• Energy Metabolism (physiology)
• Exercise (physiology)
• Humans
• Muscular Dystrophies (drug therapy)
• Treatment Outcome