Abstract | BACKGROUND/AIMS: METHODS: Direct hemoperfusion (DHP) apheresis with or without CTR for 120 min was performed in rabbits that had been intravenously infused with endotoxin and TSST-1. The mean arterial pressure was recorded and the plasma toxin and cytokine concentrations were measured during the treatment period. Mortality was assessed up to 7 days after exposure to the toxins. In addition, tissues specimens were examined using microscopy. RESULTS: The mortality rates at 7 days after the injection of the toxins were 90 and 10% for the control and CTR groups, respectively. The plasma concentrations of TSST-1, tumor necrosis factor and interleukin-1 beta in the CTR group were significantly lower than those in the control group. Histopathological examination revealed that tissue damage, such as necrosis and depletion of lymphocytes in the spleen and mesenteric lymph node, was reduced in the CTR group, compared with that in the control group, at 24 h after toxin infusion. CONCLUSION: The new adsorbent CTR improved the mortality rate in a MODS rabbit model by adsorbing TSST-1 and cytokines. Further development of CTR may expand the scope of extracorporeal therapies for patients with MODS.
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Authors | Masaji Kawatsu, Jutaro Wada, Mitsuaki Kitano, Eiji Ogino, Hiroshi Sakurai, Shigeo Furuyoshi, Nobutaka Tani |
Journal | Blood purification
(Blood Purif)
Vol. 24
Issue 3
Pg. 327-34
( 2006)
ISSN: 0253-5068 [Print] Switzerland |
PMID | 16534195
(Publication Type: Comparative Study, Journal Article)
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Copyright | Copyright 2006 S. Karger AG, Basel. |
Chemical References |
- Bacterial Toxins
- Cytokines
- Endotoxins
- Enterotoxins
- Superantigens
- enterotoxin F, Staphylococcal
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Topics |
- Animals
- Bacterial Toxins
(blood, toxicity)
- Cytokines
(blood)
- Disease Models, Animal
- Endotoxins
(blood, toxicity)
- Enterotoxins
(blood, toxicity)
- Female
- Inflammation
(prevention & control)
- Multiple Organ Failure
(chemically induced, pathology, therapy)
- Rabbits
- Sorption Detoxification
(methods)
- Superantigens
(blood, toxicity)
- Survival Rate
- Systemic Inflammatory Response Syndrome
(chemically induced, pathology, therapy)
- Time Factors
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