Hydroxyapatite granules were employed for mastoid obliteration in cases of
aural cholesteatoma. After eradicating a
cholesteatoma by the canal-down technique, the canal wall was reconstructed with cortical bone chips, and the mastoid cavity was obliterated with
hydroxyapatite granules.
Tympanoplasty by this technique was performed on 48 ears with
aural cholesteatoma. There was no recurrence of
cholesteatoma during the follow-up period of two years after surgery. One case of residual
cholesteatoma was found in the mesotympanum. There were two cases in which the
hydroxyapatite granules became exposed through the posterior canal skin. An air-bone gap of less than 20 dB was achieved in 73% of all the patients. Experimental studies in guinea pigs have demonstrated that
hydroxyapatite granules do not undergo morphological changes in and are tightly interdigitated with newly formed bone tissue growing from
bulla bone one year after
hydroxyapatite implantation in the temporal
bullae. The newly-formed bone showed incomplete osteon structures. Excellent biocompatibility and bone adaptability of
hydroxyapatite granules were demonstrated experimentally. It is concluded that
tympanoplasty with mastoid obliteration using
hydroxyapatite is safe and useful for avoiding mastoid cavity problems and for preventing the recurrence of
cholesteatoma.