[The efficacy of glucosamine in treating complicated hyperreactive experimental myocardial infarct].

Abstract

The effect of glucosamine hydrochloride on the course of complicated hyperreactive myocardial infarction in dogs was studied. Glucosamine contributed to the restoration of reactivity in the animals. The reactivity became corresponding for normoreactive myocardial infarction. Glucosamine normalized carbohydrate and protein metabolism in the necrosis zone, cAMP and cGMP and also their ratio that led to healing by postinfarction scar, and in none of the cases the heart aneurysm developed. The optimizing healing of hyperreactive myocardial infarction under the influence of glucosamine is mediated through the mechanisms of reactivity and the regulation of metabolic processes.

• Authors: V N Sokrut, I A Zupanets, N I Iabluchanskiĭ, S M Drogovoz
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1991 Mar-Apr Vol. 54 Issue 2 Pg. 31-3 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Effektivnost' gliukozamina v lechenii oslozhnennogo giperreaktovnogo éksperimental'nogo infarkta miokarda.
• PMID: 1653152 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Insulin
• Lipopolysaccharides
• Nucleotides, Cyclic
• Pyrogens
• pyrogenal
• Adrenocorticotropic Hormone
• DNA
• Glucosamine
• Hydrocortisone
• Epinephrine

Topics

• Adrenocorticotropic Hormone (blood)
• Animals
• DNA (biosynthesis)
• Disease Models, Animal
• Dogs
• Drug Evaluation, Preclinical
• Epinephrine (blood)
• Glucosamine (therapeutic use)
• Hydrocortisone (blood)
• Insulin (blood)
• Lipopolysaccharides
• Myocardial Infarction (complications, drug therapy, metabolism)
• Myocardium (metabolism)
• Nucleotides, Cyclic (blood)
• Pyrogens
• Time Factors