Abstract | PURPOSE: To describe a patient with pleomorphic adenoma arising in an accessory lacrimal gland of Wolfring in the lower lid and to illustrate the immunohistochemical and molecular cytogenetics. DESIGN: Single interventional case report. METHODS: A 62-year-old man presented with a 20-year history of a painless slowly growing mass at the temporal part of the right lower eyelid. Histological, immunohistochemical, and fluorescence in situ hybridization studies of the excised tumor were performed. RESULTS: Histological evaluation showed many glandular elements embedded in a myxoid stroma. The tumor was situated beneath an area of a normal accessory lacrimal gland of Wolfring and in close association with normal meibomian glands. Myoepithelial tumor cells in the myxoid stroma reacted strongly with an antibody against glial fibrillary acidic protein, which did not bind to normal lacrimal gland tissue. Tumor cells with both epithelial and myoepithelial morphologies reacted positively for both pleomorphic adenoma gene-1 and high-mobility group A2 proteins. Fluorescence in situ hybridization analysis showed no evidence of clonal translocations or numerical abnormalities involving chromosome 8 or 12. CONCLUSIONS:
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Authors | Ghassan A Alyahya, Göran Stenman, Fredrik Persson, Jan U Prause, Karen Skjødt, Jon P Saunte, Steffen Heegaard |
Journal | Ophthalmology
(Ophthalmology)
Vol. 113
Issue 5
Pg. 879-82
(May 2006)
ISSN: 1549-4713 [Electronic] United States |
PMID | 16530838
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adenoma, Pleomorphic
(chemistry, pathology, surgery)
- Biomarkers, Tumor
(analysis)
- Eyelid Neoplasms
(chemistry, pathology, surgery)
- Humans
- Immunoenzyme Techniques
- In Situ Hybridization, Fluorescence
- Lacrimal Apparatus Diseases
(pathology, surgery)
- Male
- Middle Aged
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