P.O.E.M.S. syndrome with complete recovery after treatment of a solitary plasmocytoma.

Abstract

The P.O.E.M.S. syndrome is a rare clinical entity that has been described mainly in Japan. It is characterized by a progressive polyneuropathy with raised CSF protein content, organomegaly, endocrinopathy, skin changes and plasma cell dyscrasia. We report a new documented case associated with a solitary plasmocytoma of the 12th thoracic vertebra. Immunopathological and ultrastructural studies of the peripheral nerve did not disclose any immune-specific changes. Surgery and radiation therapy of the plasmocytoma allowed a complete recovery, with a 5-year follow-up. This case report illustrates the need for serial full skeletal survey, including scintigraphy, in middle-aged patients with progressive polyneuropathy of obscure origin.

• Authors: E Broussolle, A Vighetto, B Bancel, C Confavreux, J Pialat, G Aimard
• Journal: Clinical neurology and neurosurgery (Clin Neurol Neurosurg) Vol. 93 Issue 2 Pg. 165-70 ( 1991) ISSN: 0303-8467 [Print] Netherlands
• PMID: 1652401 (Publication Type: Case Reports, Journal Article)

Chemical References

• Cerebrospinal Fluid Proteins

Topics

• Bone Diseases (complications, diagnostic imaging, metabolism)
• Bone and Bones (diagnostic imaging)
• Cerebrospinal Fluid Proteins (analysis)
• Endocrine System Diseases (complications, metabolism)
• Fluorescent Antibody Technique
• Hepatomegaly (complications, metabolism)
• Humans
• Male
• Middle Aged
• Neural Conduction (physiology)
• Paraproteinemias (complications, metabolism)
• Peripheral Nerves (metabolism, physiopathology)
• Plasmacytoma (complications, radiotherapy, surgery)
• Polyneuropathies (complications, metabolism)
• Radiography
• Radionuclide Imaging
• Skin Diseases (complications, metabolism)
• Syndrome