Abstract | OBJECTIVE: MATERIAL AND METHOD: ASSESSMENT: The degree of severity of nausea was determined according to the following criteria: 0: None: nausea does not occur, 1: Mild: slight nausea but no disruption to daily acitivites, 2: Moderate: nausea and some disruption to daily activities, 3: Severe: extreme nausea and severe disruption to daily activities. The control of vomiting episodes was determined according to the frequency of vomiting (including retching) as the following criteria: Complete: 0 emesis episode, Major: 1-2 emesis episodes, Minor: 3-5 emesis episodes, Failure: > 5 emesis episodes. RESULTS: The result of all 94 cycles of the first day of treatment on acute emesis (0-24 hours) were none 80.9%, mild 18.1%, and moderate 1.1% for nausea episode. For the vomiting control were complete 81.9%, major 16%, minor 1.1% and failure 1.1% respectively. The efficacy of the prevention of delayed emesis (day 2 to day 5) for nausea episode were 67%, 66%, 70.2%, and 75.5% no nausea respectively. For the vomiting control were 75.5%, 74.5%, 86.2%, and 88.3% complete control on day 2 to day 5. No serious adverse events occurred. Hiccups, constipation, and dull headache were reported as the common side effects of ramosetron. CONCLUSION:
Ramosetron combined with dexamethasone is effective for the prevention of both acute and delayed emesis associated with cisplatin. The prevention of acute emesis seems to be more effective than the prevention of delayed emesis. Adverse events were mild. No serious side effects occurred in the present study.
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Authors | Narin Voravud, Viroj Sriuranpong |
Journal | Journal of the Medical Association of Thailand = Chotmaihet thangphaet
(J Med Assoc Thai)
Vol. 88
Issue 12
Pg. 1790-6
(Dec 2005)
ISSN: 0125-2208 [Print] Thailand |
PMID | 16518975
(Publication Type: Clinical Trial, Phase II, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antiemetics
- Antineoplastic Agents
- Benzimidazoles
- Dexamethasone
- ramosetron
- Cisplatin
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Topics |
- Adult
- Aged
- Antiemetics
(administration & dosage)
- Antineoplastic Agents
(adverse effects)
- Benzimidazoles
(administration & dosage)
- Cisplatin
(adverse effects)
- Dexamethasone
(administration & dosage)
- Drug Therapy, Combination
- Female
- Humans
- Male
- Middle Aged
- Nausea
(chemically induced, prevention & control)
- Vomiting
(chemically induced, prevention & control)
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