Abstract | BACKGROUND: METHODS: We assessed 118 male patients admitted for detoxification treatment. Previous withdrawal seizures were recorded and prolactin serum levels were measured using an enzymatic immunoassay. RESULTS: Patients with a history of alcohol withdrawal seizures had significantly higher prolactin levels (17.8 ng/ml, SD=12.1) than patients without previous seizures (13.0 ng/ml, SD=8.1, p<0.05). Logistic regression revealed significant predictive qualities for prolactin serum levels (B=0.05, Wald=5.30, p=0.021, OR=1.06, 95%CI=1.01-1.11). CONCLUSIONS: The present findings show an association between elevated prolactin serum levels and a history of withdrawal seizures. Hence, the results suggest that prolactin elevation at admission may be a clinical marker for an increased risk of withdrawal seizures.
|
Authors | Thomas Hillemacher, Kristina Bayerlein, Helge Frieling, Julia Wilhelm, Marc Ziegenbein, Johannes Kornhuber, Stefan Bleich |
Journal | Journal of psychiatric research
(J Psychiatr Res)
Vol. 41
Issue 8
Pg. 702-6
(Oct 2007)
ISSN: 0022-3956 [Print] England |
PMID | 16516235
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
|
Topics |
- Adult
- Alcohol Withdrawal Seizures
(blood, diagnosis)
- Alcoholism
(blood, rehabilitation)
- Biomarkers
(blood)
- Diagnosis, Differential
- Female
- Humans
- Logistic Models
- Male
- Middle Aged
- Predictive Value of Tests
- Prolactin
(blood)
- Prospective Studies
- Risk Factors
|