[The effect of neostigmine on the motor endplate in the intermediate syndrome of organophosphate poisoning].

Abstract

A patient with severe organophosphate intoxication received Neostigmine 1 mg IV during the intermediate syndrome. This dose resulted clinically and neurophysiologically in a marked deterioration of neuro-muscular transmission. This effect of neostigmine on the neuromuscular block during the intermediate syndrome (deterioration) differs from its effect on a similar pattern (improvement), which is seen in the delayed neuropathy following organophosphate exposure. The administration of therapeutic doses of cholinesterase inhibitors in patients with a reduced safety margin due to inhibition of endplate acetylcholinesterase may be dangerous.

• Authors: R Besser
• Journal: EEG-EMG Zeitschrift fur Elektroenzephalographie, Elektromyographie und verwandte Gebiete (EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb) Vol. 22 Issue 1 Pg. 37-9 (Mar 1991) ISSN: 0012-7590 [Print] Germany
• Vernacular Title: Der Effekt von Neostigmin an der motorischen Endplatte beim Intermediärsyndrom der Alkylphosphatvergiftung.
• PMID: 1650695 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Neostigmine

Topics

• Aged
• Humans
• Male
• Motor Endplate (drug effects, physiology)
• Neostigmine (therapeutic use)
• Neuromuscular Junction (drug effects, physiology)
• Organophosphate Poisoning
• Suicide, Attempted
• Synaptic Transmission (drug effects, physiology)