Monoclonal antibodies passively protect BALB/c mice against Burkholderia mallei aerosol challenge.

Abstract

Glanders is a debilitating disease with no vaccine available. Murine monoclonal antibodies were produced against Burkholderia mallei, the etiologic agent of glanders, and were shown to be effective in passively protecting mice against a lethal aerosol challenge. The antibodies appeared to target lipopolysaccharide. Humoral antibodies may be important for immune protection against B. mallei infection.

• Authors: Sylvia R Treviño, Amy R Permenter, Marilyn J England, Narayanan Parthasarathy, Paul H Gibbs, David M Waag, Tran C Chanh
• Journal: Infection and immunity (Infect Immun) Vol. 74 Issue 3 Pg. 1958-61 (Mar 2006) ISSN: 0019-9567 [Print] United States
• PMID: 16495574 (Publication Type: Journal Article)

Chemical References

• Aerosols
• Antibodies, Bacterial
• Antibodies, Monoclonal

Topics

• Aerosols
• Animals
• Antibodies, Bacterial (administration & dosage, immunology)
• Antibodies, Monoclonal (administration & dosage, immunology)
• Burkholderia mallei (immunology)
• Glanders (immunology, mortality, prevention & control)
• Mice
• Mice, Inbred BALB C