HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Protective effect on the corneal endothelium and remaining effect at the anterior chamber for three different kinds of viscoelastic devices].

AbstractPURPOSE:
The present study was performed to evaluate the corneal endothelium protection and anterior chamber stagnation abilities of three different types of viscoelastic substances (Healon, Viscoat, HealonV).
METHODS:
Viscoelastic substances were selected at random for 120 eyes with cataracts, and the postoperative reduction rates of the corneal endothelium cells were compared. The residual viscoelastic substances after filling of the anterior chamber of pig eyes and aspiration with a handpiece were measured by an anterior eye segment image analysis system. The same procedures were performed in rabbit eyes and the residual levels of viscoelastic substances on the corneal endothelium were photographed histologically.
RESULTS:
The reduction rate of endothelium corneal cells tended to decrease with Viscoat three months after surgery. The results obtained with the anterior eye segment image analysis system showed that the residual level in the anterior chamber was higher with Healon. Histological analyses demonstrated residual Viscoat at the center of the corneal endothelium after perfusion.
CONCLUSION:
HealonV was superior in terms of spatial retention and Viscoat had corneal endothelium protection potential.
AuthorsMinako Eda, Hiroyuki Matsushima, Wataru Terauchi, Koichiro Mukai, Shinsaku Izumida, Yoshitaka Obara, Shinichiro Yoshida, Shunsuke Takeshima
JournalNippon Ganka Gakkai zasshi (Nippon Ganka Gakkai Zasshi) Vol. 110 Issue 1 Pg. 31-6 (Jan 2006) ISSN: 0029-0203 [Print] Japan
PMID16491871 (Publication Type: Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)
Chemical References
  • Drug Combinations
  • chondroitin sulfate, sodium hyaluronate drug combination
  • Hyaluronic Acid
  • Chondroitin
  • Chondroitin Sulfates
Topics
  • Aged
  • Animals
  • Anterior Chamber
  • Chondroitin (analysis, pharmacology)
  • Chondroitin Sulfates
  • Drug Combinations
  • Elasticity
  • Endothelium, Corneal (chemistry, cytology, drug effects)
  • Female
  • Humans
  • Hyaluronic Acid (analysis, pharmacology)
  • Male
  • Rabbits
  • Viscosity

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: