Pneumatosis cystoides intestinalis after alpha-glucosidase inhibitor treatment in a patient with interstitial pneumonitis.

Abstract

A 56-year-old woman was admitted to our hospital for treatment of non-specific interstitial pneumonitis (NSIP). The patient started prednisone treatment, but one month later treatment with voglibose, an alpha-glucosidase inhibitor (alpha-GI), was started because of prednisone-induced diabetes mellitus. One week later, a massive volume of free air below the diaphragm was detected by a chest X-ray examination. An abdominal CT examination demonstrated pneumatosis coli and the patient was diagnosed with pneumatosis cystoides intestinalis (PCI). Voglibose was discontinued and parenteral nutrition and oxygen inhalation were initiated. Radiographic findings of PCI disappeared within 7 days. We encountered a rare case of PCI, that was associated with alpha-GI treatment.

• Authors: Akiko Hisamoto, Takaaki Mizushima, Ken Sato, Yuro Haruta, Yasushi Tanimoto, Mitsune Tanimoto, Keisuke Matsuo
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 45 Issue 2 Pg. 73-6 ( 2006) ISSN: 1349-7235 [Electronic] Japan
• PMID: 16484742 (Publication Type: Case Reports, Journal Article)

Chemical References

• Enzyme Inhibitors
• Glucocorticoids
• Hypoglycemic Agents
• Inositol
• Glucosidases
• voglibose
• Prednisone

Topics

• Diabetes Mellitus (chemically induced, drug therapy)
• Enzyme Inhibitors (adverse effects)
• Female
• Glucocorticoids (adverse effects)
• Glucosidases (antagonists & inhibitors)
• Humans
• Hypoglycemic Agents (adverse effects)
• Inositol (adverse effects, analogs & derivatives)
• Lung Diseases, Interstitial (drug therapy)
• Middle Aged
• Pneumatosis Cystoides Intestinalis (diagnosis, etiology, pathology)
• Prednisone (adverse effects)