Abstract | AIM: METHODS: RESULTS: When introduced after two weeks of CCl4, pioglitazone reduced hepatic fibrosis, OH proline content, hepatic mRNA expression of collagen type I, and profibrotic genes, as well as the number of activated alpha smooth muscle actin positive hepatic stellate cells, compared with rats receiving CCl4 only, with no significant change in necroinflammation. When pioglitazone treatment was initiated after five weeks of CCl4, no antifibrotic effect was observed. Similarly, pioglitazone was associated with a reduced severity of fibrosis induced by a choline deficient diet when introduced early, while delayed treatment with pioglitazone remained ineffective. In contrast, pioglitazone failed to interrupt progression of fibrosis due to BDL, irrespective of the timing of its administration. CONCLUSION: In rats, the therapeutic antifibrotic efficacy of pioglitazone is limited and dependent on the type of injury, duration of disease, and/or the severity of fibrosis at the time of initiation of treatment.
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Authors | I A Leclercq, C Sempoux, P Stärkel, Y Horsmans |
Journal | Gut
(Gut)
Vol. 55
Issue 7
Pg. 1020-9
(Jul 2006)
ISSN: 0017-5749 [Print] England |
PMID | 16484506
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Collagen Type I
- Hypoglycemic Agents
- RNA, Messenger
- Thiazolidinediones
- Carbon Tetrachloride
- Choline
- Pioglitazone
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Topics |
- Animals
- Bile Ducts
(pathology)
- Carbon Tetrachloride
- Choline
(administration & dosage)
- Collagen Type I
(genetics)
- Disease Progression
- Hypoglycemic Agents
(therapeutic use)
- Ligation
- Liver Cirrhosis, Experimental
(chemically induced, drug therapy, pathology)
- Male
- Pioglitazone
- RNA, Messenger
(analysis)
- Rats
- Rats, Sprague-Dawley
- Thiazolidinediones
(therapeutic use)
- Time Factors
- Treatment Outcome
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