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B-cell tolerance following ABO-incompatible infant heart transplantation.

Abstract
Infant heart transplantation is highly successful therapy for severe congenital heart malformations and cardiomyopathies. However the donor organ shortage is particularly crucial for this age group. We have demonstrated that some aspects of human immaturity can be exploited for infant organ transplantation, allowing safe transplantation of organs that would be "incompatible" in mature individuals, and as a window of continued susceptibility to induction of immunologic tolerance.
AuthorsLori J West
JournalTransplantation (Transplantation) Vol. 81 Issue 3 Pg. 301-7 (Feb 15 2006) ISSN: 0041-1337 [Print] United States
PMID16477211 (Publication Type: Journal Article, Review)
Chemical References
  • ABO Blood-Group System
Topics
  • ABO Blood-Group System (immunology)
  • Animals
  • B-Lymphocytes (immunology)
  • Blood Group Incompatibility (immunology)
  • Heart Transplantation (immunology)
  • Humans
  • Infant
  • Male
  • Mice
  • Tissue Donors
  • Transplantation Tolerance

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