Abstract |
Plasmodium falciparum serine repeat antigen (SERA5) is a promising asexual blood stage malaria candidate vaccine. However, there is a paucity of information about natural immune responses to SERA5 in children from malaria-endemic regions. We undertook a hospital-based case-control study of severe malaria in Apac District, Northern Uganda, in children 6-59 months of age. The commonest symptoms observed in children with severe malaria (SM) were respiratory distress (53.4%) and prostration (40.4%) followed by circulatory collapse (7.4%), severe anemia (Hb < 5 g/dL, 7.0%), and seizures (2.6%). None of the SM children had impaired consciousness, coma, or cerebral malaria. We measured serum IgG antibodies using a recombinant construct of SERA5 (SE36) in enzyme-linked immunosorbent assays. High titers of IgG anti-SE36 were associated with protection against severe malaria in children under 5 years old.
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Authors | Brenda Okech, Godfrey Mujuzi, Alex Ogwal, Hiroki Shirai, Toshihiro Horii, Thomas G Egwang |
Journal | The American journal of tropical medicine and hygiene
(Am J Trop Med Hyg)
Vol. 74
Issue 2
Pg. 191-7
(Feb 2006)
ISSN: 0002-9637 [Print] United States |
PMID | 16474069
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Protozoan
- Antigens, Protozoan
- Immunoglobulin G
- Malaria Vaccines
- serine repeat antigen 5, Plasmodium falciparum
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Topics |
- Animals
- Antibodies, Protozoan
(blood)
- Antigens, Protozoan
(immunology)
- Case-Control Studies
- Child, Hospitalized
(statistics & numerical data)
- Child, Preschool
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Immunoglobulin G
(immunology)
- Infant
- Malaria Vaccines
- Malaria, Falciparum
(epidemiology, pathology, prevention & control)
- Male
- Plasmodium falciparum
(immunology)
- Severity of Illness Index
- Uganda
(epidemiology)
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