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Radiation-induced angiosarcoma of the breast shows major response to docetaxel after failure of anthracycline-based chemotherapy.

Abstract
We report on the case of a patient with a diagnosis of an uncommon breast tumour, namely a radiation-induced angiosarcoma, which was primarily refractory to anthracycline-based chemotherapy, but highly sensitive to docetaxel. Although the sarcomas in general tend to be relatively refractory to taxanes, there is some evidence that the angiosarcomas may be sensitive to these agents. This is particularly well documented with paclitaxel, but may also be the case with docetaxel.
AuthorsMax S Mano, Ghislaine Fraser, Janet Kerr, Maureen Gray, Vicky Evans, Ather Kazmi, Peter Canney
JournalBreast (Edinburgh, Scotland) (Breast) Vol. 15 Issue 1 Pg. 117-8 (Feb 2006) ISSN: 0960-9776 [Print] Netherlands
PMID16473744 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antineoplastic Agents, Phytogenic
  • Taxoids
  • Docetaxel
  • Epirubicin
  • Cyclophosphamide
  • Fluorouracil
Topics
  • Aged
  • Antineoplastic Agents, Phytogenic (therapeutic use)
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Breast Neoplasms (drug therapy, etiology)
  • Cyclophosphamide (administration & dosage)
  • Docetaxel
  • Drug Resistance, Neoplasm
  • Epirubicin (administration & dosage)
  • Female
  • Fluorouracil (administration & dosage)
  • Hemangiosarcoma (drug therapy, etiology)
  • Humans
  • Neoplasms, Radiation-Induced (drug therapy)
  • Taxoids (therapeutic use)
  • Treatment Outcome

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