Abstract |
The effect of U-50,488H, a selective kappa-receptor agonist, on memory functions in an animal model of cerebral ischemia was investigated by use of a three-panel runway task. A 5-min period of ischemia caused a significant increase in the number of errors (pushes made on the two incorrect panels of the three panel-gates at four choice points) in a working memory task but it did not impair a reference memory task. U-50,488H at 10 and 32 mg/kg, administered i.p. immediately after blood flow restoration significantly reduced the increase in errors expected to occur in a working memory task assessed 24 h after 5 min of ischemia. This protective effect of U-50,488H on amnesia in the ischemic rat was antagonized by the kappa-receptor antagonist, MR-2266. We conclude that U-50,488H prevents the impairment of working memory following transient forebrain ischemia, an event mediated by the activation of the kappa-opioid receptor.
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Authors | M Ohno, T Yamamoto, S Ueki |
Journal | European journal of pharmacology
(Eur J Pharmacol)
Vol. 193
Issue 3
Pg. 357-61
(Feb 14 1991)
ISSN: 0014-2999 [Print] Netherlands |
PMID | 1647321
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics
- Pyrrolidines
- Receptors, Opioid
- Receptors, Opioid, kappa
- 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
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Topics |
- 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
- Analgesics
(pharmacology)
- Animals
- Behavior, Animal
(drug effects)
- Brain
(blood supply)
- Brain Ischemia
(complications)
- Male
- Memory Disorders
(drug therapy, etiology)
- Pyrrolidines
(pharmacology)
- Rats
- Rats, Inbred Strains
- Receptors, Opioid
(physiology)
- Receptors, Opioid, kappa
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