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Effect of the kappa-receptor agonist, U-50,488H, on cerebral ischemia-induced impairment of working memory assessed in rats by a three-panel runway task.

Abstract
The effect of U-50,488H, a selective kappa-receptor agonist, on memory functions in an animal model of cerebral ischemia was investigated by use of a three-panel runway task. A 5-min period of ischemia caused a significant increase in the number of errors (pushes made on the two incorrect panels of the three panel-gates at four choice points) in a working memory task but it did not impair a reference memory task. U-50,488H at 10 and 32 mg/kg, administered i.p. immediately after blood flow restoration significantly reduced the increase in errors expected to occur in a working memory task assessed 24 h after 5 min of ischemia. This protective effect of U-50,488H on amnesia in the ischemic rat was antagonized by the kappa-receptor antagonist, MR-2266. We conclude that U-50,488H prevents the impairment of working memory following transient forebrain ischemia, an event mediated by the activation of the kappa-opioid receptor.
AuthorsM Ohno, T Yamamoto, S Ueki
JournalEuropean journal of pharmacology (Eur J Pharmacol) Vol. 193 Issue 3 Pg. 357-61 (Feb 14 1991) ISSN: 0014-2999 [Print] Netherlands
PMID1647321 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Analgesics
  • Pyrrolidines
  • Receptors, Opioid
  • Receptors, Opioid, kappa
  • 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
Topics
  • 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
  • Analgesics (pharmacology)
  • Animals
  • Behavior, Animal (drug effects)
  • Brain (blood supply)
  • Brain Ischemia (complications)
  • Male
  • Memory Disorders (drug therapy, etiology)
  • Pyrrolidines (pharmacology)
  • Rats
  • Rats, Inbred Strains
  • Receptors, Opioid (physiology)
  • Receptors, Opioid, kappa

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