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Dose-response effects of oral yohimbine in unrestrained primates.

Abstract
Six unrestrained bonnet macaques were each observed after oral administration of four dosages of yohimbine hydrochloride (0.10, 0.25, 0.50, and 0.75 mg/kg) and a placebo. Yohimbine significantly increased episodes of motoric activation and affective response interspersed with intervals of behavioral enervation. Yohimbine scores correlated closely with baseline levels; there was no dose-response relationship. Response to oral yohimbine differed in several ways from subcutaneous and intravenous sodium lactate infusions, including prominent enervative symptoms and the appearance of sexual arousal. In light of the appearance of cyclic enervative episodes, this study suggests limitations to primate models of panic disorder utilizing oral yohimbine.
AuthorsL A Rosenblum, J D Coplan, S Friedman, T Bassoff
JournalBiological psychiatry (Biol Psychiatry) Vol. 29 Issue 7 Pg. 647-57 (Apr 01 1991) ISSN: 0006-3223 [Print] United States
PMID1647226 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Receptors, Adrenergic
  • Yohimbine
Topics
  • Administration, Oral
  • Animals
  • Arousal (drug effects)
  • Behavior, Animal (drug effects)
  • Dose-Response Relationship, Drug
  • Locus Coeruleus (drug effects)
  • Macaca radiata
  • Male
  • Panic (drug effects)
  • Receptors, Adrenergic (drug effects)
  • Social Environment
  • Yohimbine (pharmacology)

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