[Clinicopathologic and radiologic features of dysembryoplastic neuroepithelial tumors].

Abstract

OBJECTIVE:

To study the clinicopathologic features and radiologic findings of dysembryoplastic neuroepithelial tumor (DNT).

METHODS:

The clinical presentations, radiologic findings, histologic features and immunophenotype of 9 cases of DNT were analyzed.

RESULTS:

The age of patients ranged from 12 to 51 years (mean age = 32 years). Most presented with partial seizures, sometimes accompanied by transient aphasia, agraphia and decreased visual acuity. One case was asymptomatic and discovered incidentally during a routine check-up. All patients had no neurological deficit found on physical examination. All tumors were located in the supratentorial cerebral cortex. There was no peritumoral edema or space-occupying effect on radiologic examination. The tumors involved either frontal lobe (number = 4), temporal lobe (number = 4), frontoparietal lobe (number = 1) . Two cases showed cystic changes. Two histologic variants of DNT were recognized: simple (number = 3) and complex (number = 6). Simple variant was composed mainly of the glioneuronal element, accompanied by surrounding oligodendrocyte-like cells, and the complex variant contained a low-grade glioma component, in addition to the glioneuronal element and sometimes foci of cortical dysplasia.

CONCLUSIONS:

DNT is a benign tumor with excellent prognosis after surgical excision. Local recurrence is rare. Complex variant of DNT needs to be distinguished from other types of low-grade glioma.

• Authors: Fu-lin Wang, Xiang-hang Li, Qiu-ping Gui, Lin Liu
• Journal: Zhonghua bing li xue za zhi = Chinese journal of pathology (Zhonghua Bing Li Xue Za Zhi) Vol. 34 Issue 9 Pg. 566-8 (Sep 2005) ISSN: 0529-5807 [Print] China
• PMID: 16468306 (Publication Type: English Abstract, Journal Article)

Chemical References

• Neurofilament Proteins
• S100 Proteins
• Synaptophysin

Topics

• Adolescent
• Adult
• Brain Neoplasms (complications, metabolism, pathology, surgery)
• Cerebral Cortex (metabolism, pathology)
• Child
• Child, Preschool
• Epilepsies, Partial (etiology, metabolism, pathology, surgery)
• Female
• Follow-Up Studies
• Humans
• Magnetic Resonance Imaging
• Male
• Middle Aged
• Neuroectodermal Tumors, Primitive (complications, metabolism, pathology, surgery)
• Neurofilament Proteins (metabolism)
• Oligodendroglia (pathology, ultrastructure)
• S100 Proteins (metabolism)
• Survival Rate
• Synaptophysin (metabolism)