MRI compatible electrodes for the induction of amygdala kindling in rats.

Abstract

The rat electrical kindling model has been widely utilized in epilepsy research. This study aimed to identify the optimum "MRI compatible" bipolar stimulating and recording electrodes to enable serial MRI acquisition in this model. Two types of custom-made electrodes (gold and carbon) were compared with commercial platinum-iridium alloy electrodes for suitability based on size, effect on image quality and kindling induction. The custom-made gold electrodes, based on these parameters, were found to be most suitable. These electrodes enable the study of epileptogenesis utilizing MRI in this model of temporal lobe epilepsy (TLE).

• Authors: Bianca Jupp, John P Williams, Yasvir A Tesiram, Milosh Vosmansky, Terence J O'Brien
• Journal: Journal of neuroscience methods (J Neurosci Methods) Vol. 155 Issue 1 Pg. 72-6 (Jul 15 2006) ISSN: 0165-0270 [Print] Netherlands
• PMID: 16466802 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Iridium
• Platinum
• Carbon
• Gold

Topics

• Amygdala (pathology, physiopathology)
• Animals
• Carbon (standards)
• Disease Models, Animal
• Electric Stimulation (instrumentation, methods)
• Electrodes, Implanted (standards, trends)
• Electroencephalography (instrumentation, methods)
• Epilepsy (diagnosis, physiopathology)
• Gold (standards)
• Iridium (standards)
• Kindling, Neurologic (physiology)
• Magnetic Resonance Imaging (methods, standards)
• Male
• Neurophysiology (instrumentation, methods)
• Platinum (standards)
• Rats
• Rats, Wistar