Abstract | OBJECTIVE: STUDY DESIGN: RESULTS: In both second and third trimesters, the percentage of intermediate/strong immunoreactivity of Tie-2 in the syncytiotrophoblast was significantly lower in cases than controls (P = .015 and .025, respectively). However, Tie-2 expression in the cytotrophoblastic and extravillous trophoblastic cells and Tie-1 in all trophoblast subpopulations were not significantly different between cases and controls (P > .05). The majority of Tie-2 expression, as demonstrated by Western blots, was consistent with the trends of immunohistochemical findings in the syncytiotrophoblast. Enzyme-linked immunosorbent assay in the placental lysates showed that women with placenta accreta demonstrated significantly higher angiopoietin-2 and lower Tie-2 concentrations than did women with normal pregnancies (P = .026 and .003, respectively). Placental angiopoietin-1 levels did not have any significance (P > .05). Also, angiopoietin-2 immunoreactivity in the syncytiotrophoblast was compatible with the finding demonstrated by enzyme-linked immunosorbent assay (P = .005 and .012, respectively). CONCLUSION: These observations suggest that the participation of up-regulated angiopoietin-2 and down-regulated Tie-2 in the placental tissues may indicate a role for these angiogenic factors in the development of placenta accreta.
|
Authors | Jenn J Tseng, Shih L Hsu, Esther Shih C Ho, Yun T Hsieh, Mei C Wen, Min M Chou |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 194
Issue 2
Pg. 564-71
(Feb 2006)
ISSN: 1097-6868 [Electronic] United States |
PMID | 16458662
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Angiopoietin-1
- Angiopoietin-2
- Receptor, TIE-1
- Receptor, TIE-2
|
Topics |
- Angiopoietin-1
(metabolism)
- Angiopoietin-2
(metabolism)
- Blotting, Western
- Case-Control Studies
- Enzyme-Linked Immunosorbent Assay
- Female
- Gestational Age
- Humans
- Immunohistochemistry
- Placenta
(metabolism)
- Placenta Accreta
(metabolism)
- Pregnancy
- Pregnancy Trimester, Second
(metabolism)
- Pregnancy Trimester, Third
(metabolism)
- Receptor, TIE-1
(metabolism)
- Receptor, TIE-2
(metabolism)
- Trophoblasts
(metabolism)
|