Abstract | OBJECTIVE: METHODS: RESULTS: Twenty-one patients had IgA or IgG antigliadin antibodies. Nineteen underwent jejunal biopsy. Six had mucosal alterations compatible with celiac disease; four had nonspecific histologic changes; nine had normal biopsies. Thirteen antigliadin antibody-positive patients were antiendomysial antibody-negative; one antiendomysial antibody-negative patient had celiac disease. The prevalence of celiac disease was 2.6% among 234 patients. CONCLUSIONS: Measurement of antigliadin antibodies in patients with diabetes mellitus type 1 helped in the selection of patients to undergo jejunal biopsy. Antiendomysial antibodies were highly specific and moderately sensitive in predicting celiac disease. The prevalence of celiac disease was higher in diabetics than in the general population, suggesting the need for regular screening assessment of diabetic children.
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Authors | Mariella Guarino Tanure, Ivani Novato Silva, Magda Bahia, Francisco José Penna |
Journal | Journal of pediatric gastroenterology and nutrition
(J Pediatr Gastroenterol Nutr)
Vol. 42
Issue 2
Pg. 155-9
(Feb 2006)
ISSN: 0277-2116 [Print] United States |
PMID | 16456407
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Anti-Idiotypic
- Autoantibodies
- Biomarkers
- Immunoglobulin A
- Immunoglobulin G
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Topics |
- Adolescent
- Antibodies, Anti-Idiotypic
(analysis)
- Autoantibodies
(analysis)
- Biomarkers
(blood)
- Brazil
(epidemiology)
- Celiac Disease
(blood, diagnosis, epidemiology)
- Child
- Child, Preschool
- Diabetes Mellitus, Type 1
(complications)
- Enzyme-Linked Immunosorbent Assay
- Female
- Fluorescent Antibody Technique, Indirect
- Humans
- Immunoglobulin A
(analysis)
- Immunoglobulin G
(analysis)
- Infant
- Jejunum
(pathology)
- Male
- Mass Screening
- Predictive Value of Tests
- Prevalence
- Sensitivity and Specificity
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