Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: Twenty-two good quality randomized controlled trials were included in this systematic review. The review showed that theophylline significantly improved forced expiratory volume in 1 s and forced vital capacity (weighted mean difference 0.10 L; 95% confidence interval 0.04-0.16 and weighted mean difference 0.21 L; 95% confidence interval 0.10-0.31, respectively). V also improved with theophylline (weighted mean difference 195.27 mL/min; 95% confidence interval 112.71-277.83), as did Pa and Pa (weighted mean difference 1.45 mmHg; 95% confidence interval 0.26-2.65 and weighted mean difference -1.09 mmHg; 95% confidence interval -1.83 to -0.35, respectively). Patients preferred theophylline over placebo (relative risk 2.27; 95% confidence interval 1.26-4.11). Theophylline increased the risk of nausea, however, compared with placebo (relative risk 7.67; 95% confidence interval 1.47-39.94). SUMMARY:
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Authors | Felix S F Ram |
Journal | Current opinion in pulmonary medicine
(Curr Opin Pulm Med)
Vol. 12
Issue 2
Pg. 132-9
(Mar 2006)
ISSN: 1070-5287 [Print] United States |
PMID | 16456383
(Publication Type: Journal Article, Review, Systematic Review)
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Chemical References |
- Bronchodilator Agents
- Theophylline
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Topics |
- Bronchodilator Agents
(therapeutic use)
- Double-Blind Method
- Forced Expiratory Volume
- Humans
- Pulmonary Disease, Chronic Obstructive
(drug therapy, epidemiology, physiopathology)
- Randomized Controlled Trials as Topic
- Theophylline
(therapeutic use)
- Treatment Outcome
- Vital Capacity
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