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Early growth response-1 in cardiovascular pathobiology.

Abstract
The immediate-early gene product and zinc finger transcription factor early growth response (Egr)-1 plays a key master regulatory role in multiple cardiovascular pathological processes. This article reviews the amazing recent evidence implicating Egr-1 in atherosclerosis, intimal thickening after acute vascular injury, ischemic pathology, angiogenesis, allograft rejection, and cardiac hypertrophy.
AuthorsLevon M Khachigian
JournalCirculation research (Circ Res) Vol. 98 Issue 2 Pg. 186-91 (Feb 03 2006) ISSN: 1524-4571 [Electronic] United States
PMID16456111 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Early Growth Response Protein 1
Topics
  • Animals
  • Atherosclerosis (etiology)
  • Cardiomegaly (etiology)
  • Early Growth Response Protein 1 (genetics, physiology)
  • Gene Expression Regulation
  • Graft Rejection (etiology)
  • Humans
  • Ischemia (etiology)
  • Neovascularization, Physiologic
  • Transplantation, Homologous
  • Tunica Intima (pathology)

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