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Genetic deletion of muscarinic M4 receptors is anxiolytic in the shock-probe burying model.

Abstract
We used muscarinic M2 and M4 receptor knockout (KO) mice to further explore the role of the cholinergic system in anxiety. Using the shock-probe burying model we were able to both assess anxiety and cognition. In this paradigm, an anxiolytic response is reflected by decreased burying behavior. In addition, retention latency depicts long-term memory performance. Whereas muscarinic M2 receptor KO mice did not differ behaviorally from wild-type mice, muscarinic M4 receptor KO mice showed increased anxiolysis, but normal long-term memory compared to wild-type mice. Therefore, muscarinic M4 receptors are of particular significance in anxiety modulation that seems dissociated from changes in long-term memory.
AuthorsAldemar Degroot, George G Nomikos
JournalEuropean journal of pharmacology (Eur J Pharmacol) Vol. 531 Issue 1-3 Pg. 183-6 (Feb 15 2006) ISSN: 0014-2999 [Print] Netherlands
PMID16455072 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Receptor, Muscarinic M2
  • Receptor, Muscarinic M4
Topics
  • Animals
  • Anxiety (physiopathology)
  • Behavior, Animal (physiology)
  • Electroshock
  • Female
  • Gene Deletion
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Models, Animal
  • Receptor, Muscarinic M2 (genetics, physiology)
  • Receptor, Muscarinic M4 (genetics, physiology)
  • Time Factors

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