Abstract |
We used muscarinic M2 and M4 receptor knockout (KO) mice to further explore the role of the cholinergic system in anxiety. Using the shock-probe burying model we were able to both assess anxiety and cognition. In this paradigm, an anxiolytic response is reflected by decreased burying behavior. In addition, retention latency depicts long-term memory performance. Whereas muscarinic M2 receptor KO mice did not differ behaviorally from wild-type mice, muscarinic M4 receptor KO mice showed increased anxiolysis, but normal long-term memory compared to wild-type mice. Therefore, muscarinic M4 receptors are of particular significance in anxiety modulation that seems dissociated from changes in long-term memory.
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Authors | Aldemar Degroot, George G Nomikos |
Journal | European journal of pharmacology
(Eur J Pharmacol)
Vol. 531
Issue 1-3
Pg. 183-6
(Feb 15 2006)
ISSN: 0014-2999 [Print] Netherlands |
PMID | 16455072
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Receptor, Muscarinic M2
- Receptor, Muscarinic M4
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Topics |
- Animals
- Anxiety
(physiopathology)
- Behavior, Animal
(physiology)
- Electroshock
- Female
- Gene Deletion
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Models, Animal
- Receptor, Muscarinic M2
(genetics, physiology)
- Receptor, Muscarinic M4
(genetics, physiology)
- Time Factors
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