Abstract | STUDY OBJECTIVE: DESIGN: Genetic association study in patients with PD. SETTING: PARTICIPANTS: PD patients with and without episodes of suddenly falling asleep matched for antiparkinsonian medication, disease duration, sex, and age, who participated in a previous genetic study on dopamine-receptor polymorphisms. INTERVENTIONS: Not applicable. MEASUREMENTS AND RESULTS: In this study, 240 patients with PD (154 men; age 65.1 +/- 6.1 years; disease duration 9.4 +/- 6.0 years) were included. Seventy had the met-met (LL), 116 the met-val (LH), and 54 the val-val (HH) genotype. In the combined LL+LH group (featuring reduced COMT activity), the mean Epworth Sleepiness Scale (ESS) score was 9.0 +/- 5.9 versus 11.0 +/- 6.1 in the HH (high COMT activity) group (P = .047). Forty-seven percent of the LL and LH patients had sudden sleep onset compared with 61% of the HH patients (P = .07). Logistic regression, however, showed that both pathologic ESS scores (i. e., > 10) and sudden sleep onset were predicted by subjective disease severity (P < .001 each) but not by the COMT genotype. CONCLUSIONS: Our previous finding that the L-allele may be associated with daytime sleepiness could not be confirmed in the present study. Altogether, our data do not support a clinically relevant effect of the COMT genotype on daytime sleepiness in PD.
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Authors | Ida Rissling, Birgit Frauscher, Florian Kronenberg, Mehdi Tafti, Karin Stiasny-Kolster, Anne-Catherine Robyr, Yvonne Körner, Wolfgang Hermann Oertel, Werner Poewe, Birgit Högl, Jens Carsten Möller |
Journal | Sleep
(Sleep)
Vol. 29
Issue 1
Pg. 108-11
(Jan 2006)
ISSN: 0161-8105 [Print] United States |
PMID | 16453988
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Codon
- Dopamine Agonists
- Catechol O-Methyltransferase
- Dopamine
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Topics |
- Aged
- Catechol O-Methyltransferase
(genetics)
- Circadian Rhythm
- Codon
- Disorders of Excessive Somnolence
(epidemiology, genetics)
- Dopamine
(genetics)
- Dopamine Agonists
(therapeutic use)
- Female
- Genotype
- Humans
- Male
- Middle Aged
- Parkinson Disease
(drug therapy, epidemiology)
- Polymorphism, Genetic
(genetics)
- Reverse Transcriptase Polymerase Chain Reaction
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