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Diabetes insipidus due to herpes encephalitis in a patient with diffuse large cell lymphoma. A case report.

Abstract
The major causes of central diabetes insipidus are neoplastic or infiltrative lesions of the hypothalamus or pituitary, severe head injuries and pituitary or hypothalamic surgery. Central diabetes insipidus caused by viral infections has been rarely reported in immunosuppressed patients, such as those with acquired immunodeficiency syndrome or Cushing's syndrome. We report the case of a 48-year-old woman suffering from diffuse large cell lymphoma, who developed hypotonic polyuria, hypernatriaemia and somnolence after the first course of chemotherapy with CHOEP and rituximab. Diabetes insipidus was diagnosed by low urine osmolarity and an undetectable vasopressin concentration. MRI revealed no pituitary abnormalities but encephalitis, and lumbar punction confirmed herpes zoster infection. To the best of our knowledge this is the first description of central diabetes insipidus in a lymphoma patient caused by an opportunistic CNS-infection.
AuthorsK Scheinpflug, E Schalk, K Reschke, A Franke, M Mohren
JournalExperimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association (Exp Clin Endocrinol Diabetes) Vol. 114 Issue 1 Pg. 31-4 (Jan 2006) ISSN: 0947-7349 [Print] Germany
PMID16450314 (Publication Type: Case Reports, Journal Article)
Topics
  • Brain (pathology)
  • Cerebral Ventricles (pathology)
  • Diabetes Insipidus (etiology)
  • Encephalitis, Herpes Simplex (complications)
  • Fatal Outcome
  • Female
  • Humans
  • Lymphoma, Large B-Cell, Diffuse (complications)
  • Magnetic Resonance Spectroscopy
  • Middle Aged

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