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Cortistatin-17 and somatostatin-14 display the same effects on growth hormone, prolactin, and insulin secretion in patients with acromegaly or prolactinoma.

AbstractCONTEXT:
Cortistatin binds all somatostatin receptor subtypes but also has particular central actions; moreover, a specific cortistatin receptor has also been discovered.
OBJECTIVE:
We compared the endocrine effects of cortistatin-17 with those of somatostatin-14 in patients with acromegaly (ACRO) or prolactinoma (PRLOMA). Normal subjects (NS) were studied as control group.
DESIGN:
All subjects underwent the following tests: 1) saline, 2) somatostatin-14 (2.0 microg/kg.h iv, 0-120 min) and 3) cortistatin-17 (2.0 microg/kg.h iv, 0-120 min) infusion.
RESULTS:
Cortistatin-17 and somatostatin-14 inhibited GH secretion to the same extent in ACRO (P < 0.05) and NS (P < 0.01). Cortistatin-17 and somatostatin-14 inhibited PRL secretion in PRLOMA (P < 0.05), to some extent in ACRO (P value not significant), but not in NS. Insulin secretion was inhibited by both cortistatin-17 and somatostatin-14 to the same extent in all groups (P < 0.05).
CONCLUSIONS:
Cortistatin-17 and somatostatin-14 display the same effects on GH, PRL, and insulin secretion in patients with ACRO or PRLOMA.
AuthorsS Grottoli, V Gasco, F Broglio, R Baldelli, F Ragazzoni, F Gallenca, A Mainolfi, F Prodam, G Muccioli, E Ghigo
JournalThe Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 91 Issue 4 Pg. 1595-9 (Apr 2006) ISSN: 0021-972X [Print] United States
PMID16449338 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Blood Glucose
  • CORT protein, human
  • Carrier Proteins
  • Insulin
  • Neuropeptides
  • Human Growth Hormone
  • Somatostatin
  • Prolactin
  • Glucose Oxidase
Topics
  • Acromegaly (blood)
  • Adult
  • Aged
  • Area Under Curve
  • Blood Glucose (metabolism)
  • Body Mass Index
  • Carrier Proteins (adverse effects, pharmacology)
  • Female
  • Glucose Oxidase (metabolism)
  • Human Growth Hormone (blood)
  • Humans
  • Insulin (blood)
  • Male
  • Middle Aged
  • Neuropeptides (adverse effects, pharmacology)
  • Pituitary Neoplasms (blood)
  • Prolactin (blood)
  • Prolactinoma (blood)
  • Somatostatin (adverse effects, pharmacology)

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