Effect of fenofibrate on the level of asymmetric dimethylarginine in individuals with hypertriglyceridemia.

Abstract

OBJECTIVE:

To test whether treatment with fenofibrate decreases asymmetric dimethylarginine (ADMA) level in hypertriglyceridemic individuals.

METHODS:

In the present study, 45 subjects with hypertriglyceridemia were recruited to receive treatment with fenofibrate (200 mg/d). Serum concentrations of ADMA, malondialdehyde (MDA), nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) were measured. Endothelial function assessed by flow-mediated dilation (FMD) of the brachial artery was performed.

RESULTS:

Compared with control, serum levels of ADMA (0.47+/-0.05 micromol/L in control and 0.62+/-0.28 micromol/L in hypertriglyceridemic patients, P<0.01), MDA and TNF-alpha were markedly elevated, and the level of NO was significantly reduced, concomitantly with impaired endothelium-dependent vasodilation in individuals with hypertriglyceridemia. 8-week treatment with fenofibrate significantly reduced the elevated levels of ADMA (0.53+/-0.12 micromol/L, P<0.01), MDA and TNF-alpha, attenuated the decreased level of NO and improved endothelial function.

CONCLUSIONS:

These results suggest that the beneficial effect of fenofibrate on the endothelium in hypertriglyceridemic individuals may be related to reduction of ADMA level.

• Authors: Tian-Lun Yang, Mei-Fang Chen, Xin Xia, Bai-Lin Luo, Yuan-Jian Li
• Journal: European journal of clinical pharmacology (Eur J Clin Pharmacol) Vol. 62 Issue 3 Pg. 179-84 (Mar 2006) ISSN: 0031-6970 [Print] Germany
• PMID: 16447050 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticholesteremic Agents
• Cholesterol, HDL
• Triglycerides
• Tumor Necrosis Factor-alpha
• Nitric Oxide
• Malondialdehyde
• N,N-dimethylarginine
• Arginine
• Cholesterol
• Fenofibrate

Topics

• Adult
• Anticholesteremic Agents (pharmacology, therapeutic use)
• Arginine (analogs & derivatives, blood)
• Blood Flow Velocity (drug effects)
• Brachial Artery (drug effects, metabolism)
• Cholesterol (blood)
• Cholesterol, HDL (blood)
• Diet
• Endothelium, Vascular (drug effects, metabolism)
• Female
• Fenofibrate (pharmacology, therapeutic use)
• Humans
• Hypertriglyceridemia (blood, diet therapy, drug therapy)
• Male
• Malondialdehyde (blood)
• Middle Aged
• Nitric Oxide (blood)
• Treatment Outcome
• Triglycerides (blood)
• Tumor Necrosis Factor-alpha (metabolism)
• Vasodilation (drug effects)