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Microarray analysis of selenium-depleted and selenium-supplemented mice.

Abstract
Nutritional selenium deficiency is associated with Keshan disease in humans and white muscle disease in ruminant livestock. In this study, mice were fed a selenium-deficient diet for three generations. Female mice from the third depleted generation of these mice were given water containing either no added selenium or 0.1 or 1.0 ppm selenium as sodium selenate; DNA microarrays were used to compare gene expression in the muscle from mice fed the selenium diets to that from mice remaining on the depleted diet. The most prominent expression increases were observed with Ptger2 (a prostaglandin E receptor), Tcrb-V13 (a T-cell receptor beta), Tcf-7 (a T-cell transcription factor), and Lck (lymphocyte protein tyrosine kinase), and the major consistent decrease was Vav2, an oncogene in mice consuming the selenium containing diets.
AuthorsL A Hooven, J Butler, L W Ream, P D Whanger
JournalBiological trace element research (Biol Trace Elem Res) Vol. 109 Issue 2 Pg. 173-79 (Feb 2006) ISSN: 0163-4984 [Print] United States
PMID16444006 (Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural)
Chemical References
  • Hepatocyte Nuclear Factor 1-alpha
  • Hnf1a protein, mouse
  • Proto-Oncogene Proteins c-vav
  • Receptors, Antigen, T-Cell, alpha-beta
  • Receptors, Prostaglandin E
  • T Cell Transcription Factor 1
  • Transcription Factors
  • Vav2 protein, mouse
  • DNA
  • Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
  • Selenium
Topics
  • Animals
  • DNA (analysis, metabolism)
  • Dietary Supplements
  • Female
  • Gene Expression Regulation (drug effects)
  • Hepatocyte Nuclear Factor 1-alpha
  • Lymphocyte Specific Protein Tyrosine Kinase p56(lck) (biosynthesis, genetics)
  • Mice
  • Mice, Inbred Strains
  • Muscle, Skeletal (metabolism)
  • Oligonucleotide Array Sequence Analysis
  • Proto-Oncogene Proteins c-vav (biosynthesis, genetics)
  • Receptors, Antigen, T-Cell, alpha-beta (biosynthesis, genetics)
  • Receptors, Prostaglandin E (biosynthesis, genetics)
  • Selenium (administration & dosage, deficiency, pharmacology)
  • T Cell Transcription Factor 1 (biosynthesis, genetics)
  • Transcription Factors (biosynthesis, genetics)

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