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Hyperbaric oxygenation and antioxidant vitamin combination reduces ischemia-reperfusion injury in a rat epigastric island skin-flap model.

Abstract
Reperfusion injury, caused by free oxygen radicals, is a chain of events that occurs in tissues exposed to a constant period of ischemia. The antioxidant vitamins E and C (VEC) and hyperbaric oxygenation (HBO) have beneficial effects in treating ischemic tissues following skin flap operations. In our study, we aimed to compare the effects of VEC and/or HBO in ischemia-reperfusion injury induced by free oxygen radicals in an experimental rat epigastric island skin-flap model. Eight hours of ischemia was provided by clamping the inferior epigastric pedicle following the flap elevation. The flap survey was determined to be 28.6% in controls, 59.2% in HBO group, 66.3% in VEC + HBO group, and 82% in VEC group (p < 0.05). We conclude that although HBO and/or VEC increased the flap viability significantly by reducing ischemia-reperfusion injury, the most promising results were obtained in the antioxidant vitamins group.
AuthorsAhmet Tomur, Ozdal Etlik, Nimet Unay Gundogan
JournalJournal of basic and clinical physiology and pharmacology (J Basic Clin Physiol Pharmacol) Vol. 16 Issue 4 Pg. 275-85 ( 2005) ISSN: 0792-6855 [Print] Germany
PMID16438393 (Publication Type: Journal Article)
Chemical References
  • Antioxidants
  • Reactive Oxygen Species
  • Vitamins
  • Vitamin E
  • Adenosine Triphosphate
  • Ascorbic Acid
  • Oxygen
Topics
  • Adenosine Triphosphate (metabolism)
  • Animals
  • Antioxidants (pharmacology)
  • Ascorbic Acid (blood, pharmacology)
  • Female
  • Hyperbaric Oxygenation
  • Lipid Peroxidation (drug effects)
  • Oxygen (blood)
  • Oxygen Consumption (drug effects)
  • Rats
  • Rats, Sprague-Dawley
  • Reactive Oxygen Species (metabolism)
  • Reperfusion Injury (prevention & control)
  • Surgical Flaps
  • Vitamin E (blood, pharmacology)
  • Vitamins (pharmacology)

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