Abstract |
Reperfusion injury, caused by free oxygen radicals, is a chain of events that occurs in tissues exposed to a constant period of ischemia. The antioxidant vitamins E and C (VEC) and hyperbaric oxygenation (HBO) have beneficial effects in treating ischemic tissues following skin flap operations. In our study, we aimed to compare the effects of VEC and/or HBO in ischemia-reperfusion injury induced by free oxygen radicals in an experimental rat epigastric island skin-flap model. Eight hours of ischemia was provided by clamping the inferior epigastric pedicle following the flap elevation. The flap survey was determined to be 28.6% in controls, 59.2% in HBO group, 66.3% in VEC + HBO group, and 82% in VEC group (p < 0.05). We conclude that although HBO and/or VEC increased the flap viability significantly by reducing ischemia-reperfusion injury, the most promising results were obtained in the antioxidant vitamins group.
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Authors | Ahmet Tomur, Ozdal Etlik, Nimet Unay Gundogan |
Journal | Journal of basic and clinical physiology and pharmacology
(J Basic Clin Physiol Pharmacol)
Vol. 16
Issue 4
Pg. 275-85
( 2005)
ISSN: 0792-6855 [Print] Germany |
PMID | 16438393
(Publication Type: Journal Article)
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Chemical References |
- Antioxidants
- Reactive Oxygen Species
- Vitamins
- Vitamin E
- Adenosine Triphosphate
- Ascorbic Acid
- Oxygen
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Topics |
- Adenosine Triphosphate
(metabolism)
- Animals
- Antioxidants
(pharmacology)
- Ascorbic Acid
(blood, pharmacology)
- Female
- Hyperbaric Oxygenation
- Lipid Peroxidation
(drug effects)
- Oxygen
(blood)
- Oxygen Consumption
(drug effects)
- Rats
- Rats, Sprague-Dawley
- Reactive Oxygen Species
(metabolism)
- Reperfusion Injury
(prevention & control)
- Surgical Flaps
- Vitamin E
(blood, pharmacology)
- Vitamins
(pharmacology)
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